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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 66 - 72 (7page)
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Pathological hypertrophy of the heart is closely associated with endoplasmic reticulum stress (ERS), leading to mal-adaptations such as myocardial fibrosis, induction of apoptosis, and cardiac dysfunctions. Salubrinal is a known selective inhibitor of protein phosphatase 1 (PP1) complex involving dephosphorylation of phospho-eukaryotic translation initiation factor 2 subunit (p-eIF2)-?, the key signaling process in the ERS pathway. In this study, the effects of salubrinal were examined on cardiac hypertrophy using the mouse model of transverse aortic constriction (TAC) and cell model of neonatal rat ventricular myocytes (NRVMs). Treatment of TAC-induced mice with salubrinal (0.5 mg?kg-1?day-1) alleviated cardiac hypertrophy and tissue fibrosis. Salubrinal also alleviated hypertrophic growth in endothelin 1 (ET1)-treated NRVMs. Therefore, the present results suggest that salubrinal may be a potentially efficacious drug for treating pathological cardiac remodeling.
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참고문헌 (33)
참고문헌 신청
Annes, J. P. / 2003 / Making sense of latent TGFbeta activation / J. Cell Sci 116:217~224
Berenji, K. / 2005 / Does load-induced ventricular hypertrophy progress to systolic heart failure? / Am. J. Physiol. Heart Circ. Physiol 289:H8~H16
Boyce, M. / 2005 / A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress / Science 307:935~939
Cnop, M. / 2007 / Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis / J. Biol. Chem 282:3989~3997
Desmouliere, A. / 1993 / Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts / J. Cell Biol 122:103~111
Berenji, K. / 2005 / Does load-induced ventricular hypertrophy progress to systolic heart failure? / Am. J. Physiol. Heart Circ. Physiol 289:H8~H16
Boyce, M. / 2005 / A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress / Science 307:935~939
Cnop, M. / 2007 / Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis / J. Biol. Chem 282:3989~3997
Desmouliere, A. / 1993 / Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts / J. Cell Biol 122:103~111
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