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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.8
- 수록면
- 705 - 716 (12page)
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초록· 키워드
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The endoplasmic reticulum (ER) is a critical organelle for protein synthesis, folding and modification, and lipid synthesis and calcium storage. Dysregulation of ER functions leads to the accumulation of misfolded- or unfolded-protein in the ER lumen, and this triggers the unfolded protein response (UPR), which restores ER homeostasis. The UPR is characterized by three distinct downstream signaling pathways that promote cell survival or apoptosis depending on the stressor, the intensity and duration of ER stress, and the cell type. Mammalian cells express the UPR transducers IRE1, PERK, and ATF6, which control transcriptional and translational responses to ER stress. Direct links between ER stress and immune responses are also evident, but the mechanisms by which UPR signaling cascades are coordinated with immunity remain unclear. This review discusses recent investigations of the roles of ER stress in immune responses that lead to differentiation, maturation, and cytokine expression in immune cells. Further understanding of how ER stress contributes to the pathogenesis of immune dis-orders will facilitate the development of novel therapies that target UPR pathways.
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등록된 정보가 없습니다.
참고문헌 (103)
참고문헌 신청
Acosta-Alvear, D. / 2007 / XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks / Mol. Cell 27:53~66
Adachi, Y. / 2008 / ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum / Cell Struct. Funct. 33:75~89
Ansa-Addo, E.A. / 2016 / Clients and oncogenic roles of molecular chaperone gp96/grp94 / Curr. Top. Med. Chem. 16:2765~2778
Bertolotti, A. / 2000 / Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response / Nat. Cell Biol. 2:326~332
Bettigole, S.E. / 2015 / Endoplasmic reticulum stress in immunity / Annu. Rev. Immunol. 33:107~138
Adachi, Y. / 2008 / ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum / Cell Struct. Funct. 33:75~89
Ansa-Addo, E.A. / 2016 / Clients and oncogenic roles of molecular chaperone gp96/grp94 / Curr. Top. Med. Chem. 16:2765~2778
Bertolotti, A. / 2000 / Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response / Nat. Cell Biol. 2:326~332
Bettigole, S.E. / 2015 / Endoplasmic reticulum stress in immunity / Annu. Rev. Immunol. 33:107~138
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