메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
최철희 (주식회사 일리아스바이오로직스)
저널정보
대한생화학·분자생물학회 BMB Reports BMB Reports 제55권 제1호
발행연도
2022.1
수록면
1 - 2 (2page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Extracellular vesicles (EVs), especially exosomes, are cell-derivednanoparticles harboring various cellular components such asRNAs, lipids, and proteins for intercellular communication. Rolesof EVs as intercellular communicators have been extensivelystudied in the last few decades, especially under various pathologicalconditions. Deciphering the message in EVs isolated frombiological fluids of patients can provide valuable informationnot only for disease diagnosis, but also for disease monitoringor treatment responses. EVs are also attractive treatment modalityand drug delivery system with favorable properties of biocompatibility,selective tropism, and stability. Stem cell-derived naiveEVs have been tested for their regenerative or immunomodulatoryeffects in numerous preclinical and clinical studies. Thisso-called “cell-free cell therapy” is supported by the idea thatmost therapeutic actions of conventional cell therapy are mediatedby paracrine action of EVs released from stem cells. Inthat sense, immune cell-derived EVs are regarded as a reasonableoption for cancer immunotherapy. Such therapeutic effectof EVs can be dramatically augmented by incorporating activepharmaceutical ingredients (APIs) to make engineered exosomesas “Trojan Horses”. Biomimetic EVs or cell-derived nanovesiclescan be generated through various physicochemical methos suchas serial extrusion. They provide alternative options due to theirhigh productivity and relatively easy purification. In this specialissue, therapeutic applications of naive or engineered EVs arediscussed in various human diseases including cardiovasculardiseases, renal disorders, neurological diseases, cancers, andinfectious diseases focusing on COVID-19.

목차

등록된 정보가 없습니다.

참고문헌 (0)

참고문헌 신청

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0