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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 667 - 678 (12page)
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초록· 키워드
오류제보하기
Extracellular vesicles (EVs), a heterogenous group of membrane-bound particles, are virtually secreted by all cells and play important roles in cell–cell communication. Loaded with proteins, mRNAs, non-coding RNAs and membrane lipids from their donor cells, these vesicles participate in normal physiological and pathogenic processes. In addition, these subcellular vesicles are implicated in the progression of neurodegenerative disorders. Accumulating evidence suggests that intercellular communication via EVs is responsible for the propagation of key pathogenic proteins involved in the pathogenesis of amyotrophic lateral sclerosis, Parkinson’s diseases, Alzheimer’s diseases and other neurodegenerative disorders. For therapeutic perspective, EVs present advantage over other synthetic drug delivery systems or cell therapy; ability to cross biological barriers including blood brain barrier (BBB), ability to modulate inflammation and immune responses, stability and longer biodistribution with lack of tumorigenicity. In this review, we summarized the current state of EV research in central nervous system in terms of their values in diagnosis, disease pathology and therapeutic applications.
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등록된 정보가 없습니다.
참고문헌 (6)
참고문헌 신청
Mooi Tiong Liau / 2016 / The Therapeutic Potential of Stem Cells and Progenitor Cells for the Treatment of Parkinson’s Disease / 조직공학과 재생의학 13(5):455~464
윤준원 / 2016 / Behavior, PET and Histology in Novel Regimen of MPTP Marmoset Model of Parkinson’s Disease for Long-Term Stem Cell Therapy / 조직공학과 재생의학 13(1):100~109
김상화 / 2015 / Effects of Adipose-Derived Stem Cells on Keloid Fibroblasts Based on Paracrine Function / 조직공학과 재생의학 12(6):435~441
박정현 / 2016 / Characterization of Adipose Tissue Mesenchymal Stromal Cell Subsets with Distinct Plastic Adherence / 조직공학과 재생의학 13(1):39~46
ChongYang Shen / 2015 / Dental Pulp Stem Cells derived Conditioned Medium Promotes Angiogenesis in Hindlimb Ischemia / 조직공학과 재생의학 12(1):59~68
윤준원 / 2016 / Behavior, PET and Histology in Novel Regimen of MPTP Marmoset Model of Parkinson’s Disease for Long-Term Stem Cell Therapy / 조직공학과 재생의학 13(1):100~109
김상화 / 2015 / Effects of Adipose-Derived Stem Cells on Keloid Fibroblasts Based on Paracrine Function / 조직공학과 재생의학 12(6):435~441
박정현 / 2016 / Characterization of Adipose Tissue Mesenchymal Stromal Cell Subsets with Distinct Plastic Adherence / 조직공학과 재생의학 13(1):39~46
ChongYang Shen / 2015 / Dental Pulp Stem Cells derived Conditioned Medium Promotes Angiogenesis in Hindlimb Ischemia / 조직공학과 재생의학 12(1):59~68
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