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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.6
- 수록면
- 59 - 65 (7page)
- DOI
- 10.5145/ACM.2022.25.2.4
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초록· 키워드
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Background: Recently, CrpP enzymes have been described as a novel cause of ciprofloxacinresistance. The crpP gene encodes a novel protein that specifically confers resistance tociprofloxacin through an adenosine triphosphate-dependent mechanism that phosphorylatesthe antimicrobial. In this study, the current prevalence of the crpP gene in carbapenemaseproducingPseudomonas aeruginosa blood isolates was evaluated.
Methods: During the study of the Antimicrobial Resistance Surveillance System in Korea, 22blood isolates of carbapenemase-producing P. aeruginosa were collected from nine generalhospitals and two nursing homes in the year 2020. Resistance genes and phylogenic trees wereanalyzed with the whole genome sequencing data.
Results: A total of 11 P. aeruginosa blood isolates coharbored the crpP and carbapenemasegenes (nine IMP-6 producers and two GES-5-producers). Nine NDM-1-producers coharboredaac(6')-Ib-cr and qnrVC1. One GES-9-producer also carried aac(6')-Ib-cr, and one NDM-1-producer also carried qnrVC1. The phylogenic tree showed no epidemiologic link among the 22carbapenemase-producing P. aeruginosa isolates.
Conclusion: This is the first report on the current prevalence of the crpP gene in carbapenemaseproducingP. aeruginosa blood isolates in Korea.
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