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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 33 - 40 (8page)
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초록· 키워드
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Background: The aim of this study was to investigate the molecular epidemiological characteristics of metallo-β-lactamase(MBL)-producing Pseudomonas aeruginosa clinical isolates in Korea.
Materials and Methods: Three hundred and twenty nine P. aeruginosa clinical isolates were collected from 23 general hospitalsin Korea from March to June 2014. Species were identified by matrix-assited laser desorption/ionization-time of flight and 16SrRNA sequencing. Antimicrobial susceptibility was determined by disk diffusion methods. Further, minimum inhibitory concentrationsof carbapenems were determined by Etest. Polymerase chain reaction and sequencing were performed to identify genesencoding MBLs. Multi-locus sequence typing and pulsed-field gel electrophoresis were performed to determine epidemiologicalcharacteristics of MBL-producing P. aeruginosa isolates.
Results: Of the 329 isolates, 229 (69.6%) were susceptible to the carbapenems tested, including imipenem and meropenem;while 100 (30.4%) were non-susceptible to more than one of the carbapenems. Genes encoding imipenemase-6 (IMP-6) andVerona imipenemase-2 (VIM-2) MBLs were identified in 21 (6.4%) isolates (n = 17 and 4, respectively). All MBL-producing isolatesshowed multi-drug resistant phenotype, and a majority (n = 19) of the isolates were identified as sequence type 235 (ST235).
The remaining isolates (n = 2) were identified as ST309 and ST463.
Conclusion: P. aeruginosa ST235 might play an important role in dissemination of MBL genes in Korea.
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참고문헌 (21)
참고문헌 신청
Bae IK / 2011 / Interspecies dissemination of the bla gene encoding PER-1 extended-spectrum β-lactamase. / Antimicrob Agents Chemother 55 : 1305 ~ 1307
Castanheira M / 2014 / Epidemiology and carbapenem resistance mechanisms of carbapenem-non-susceptible Pseuomonas aeruginosa collected during 2009-11 in 14 European and Medi
Clinical and Laboratory Standards Institute / 2014 / Performance standards for antimicrobial susceptibility testing: twenty-fourth informational supplement (M100-S24) / CLSI
Curran B / 2004 / Development of a multilocus sequence typing scheme for the opportunistic pathogen Pseudomonas aeruginosa / J Clin Microbiol 42 : 5644 ~ 5649
Diene SM / 2014 / Carbapenemase genes and genetic platforms in Gram-negative bacilli: Enterobacteriaceae, Pseudomonas and Acinetobacter species / Clin Microbiol Infect 20 : 8
Castanheira M / 2014 / Epidemiology and carbapenem resistance mechanisms of carbapenem-non-susceptible Pseuomonas aeruginosa collected during 2009-11 in 14 European and Medi
Clinical and Laboratory Standards Institute / 2014 / Performance standards for antimicrobial susceptibility testing: twenty-fourth informational supplement (M100-S24) / CLSI
Curran B / 2004 / Development of a multilocus sequence typing scheme for the opportunistic pathogen Pseudomonas aeruginosa / J Clin Microbiol 42 : 5644 ~ 5649
Diene SM / 2014 / Carbapenemase genes and genetic platforms in Gram-negative bacilli: Enterobacteriaceae, Pseudomonas and Acinetobacter species / Clin Microbiol Infect 20 : 8
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