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논문 기본 정보

자료유형
학술저널
저자정보
서문영 (원진녹색병원 소아청소년과) 문신제 (한림대학교) 김신혜 (인제대학교) 박미정 (인제대학교)
저널정보
대한내분비학회 Endocrinology and Metabolism Endocrinology and Metabolism Vol.37 No.2
발행연도
2022.4
수록면
249 - 260 (12page)
DOI
https://doi.org/10.3803/EnM.2021.1235

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Background: Phthalates and bisphenol A (BPA) are synthetic chemicals widely used in daily life. This study investigated urinaryphthalate and BPA levels in Korean children and their associations with obesity. Methods: A total of 2,351 children aged 3 to 17 years who participated in the Korean National Environmental Health Survey 2015to 2017 were included. Urinary dilution was corrected using covariate-adjusted standardization (CAS). We examined the geometricmean (GM) concentrations of urinary phthalate metabolites, including di (2-ethylhexyl) phthalate (DEHP) metabolites (mono [2-ethyl-5-hydroxyhexyl] phthalate, mono [2-ethyl-5-oxohexyl] phthalate, and mono [2-ethyl-5-carboxypentyl] phthalate [MECPP]), mono-benzyl-phthalate (MBzP), mono (carboxyoctyl) phthalate (MCOP), mono (carboxy-isononyl) phthalate (MCNP), mono (3-carboxypropyl) phthalate, and mono-n-butyl-phthalate (MnBP), and BPA. We also analyzed the odds ratio (OR) for obesity accordingto the quartiles of each analyte. Results: The urinary GM levels of DEHP metabolites and MnBP were notably higher among Korean children than among American, Canadian, and German children. The CAS-applied GM concentrations of most analytes, except for MBzP, MCOP, and MCNP,were higher in children aged 3 to 5 years than in those aged 6 to 17 years. The OR for obesity in the highest quartile of MECPP wassignificantly higher than in the lowest quartile after adjusting for covariates. However, the other phthalate metabolites and BPA werenot significantly associated with obesity. Conclusion: The concentrations of urinary DEHP metabolites and MnBP were higher in Korean children than in children in Westerncountries. Urinary MECPP exposure, but not other phthalates or BPA, showed a positive association with obesity in Korean children. Further studies are required to elucidate the causal relationships

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