Associations Between Thyroid Hormone Levels and Urinary Concentrations of Bisphenol A, F, and S in 6-Year-old Children in Korea

Jang Yoonyoung; Choi Yoon-Jung; Lim Youn-Hee; Lee Kyung-Shin; Kim Bung-Nyun; Shin Choong Ho; Lee Young Ah; Kim Johanna Inhyang; 홍윤철

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저자정보: Jang Yoonyoung (Department of Preventive Medicine Seoul National University College of Medicine Seoul Korea) Choi Yoon-Jung (Department of Preventive Medicine Seoul National University College of Medicine Seoul Korea) Lim Youn-Hee (Seoul National University Medical Research Center Seoul Korea) Lee Kyung-Shin (Department of Preventive Medicine Seoul National University College of Medicine Seoul Korea) Kim Bung-Nyun (Department of Psychiatry Seoul National University College of Medicine Seoul Korea) Shin Choong Ho (National University College of Medicine Seoul Korea) Lee Young Ah (National University College of Medicine Seoul Korea) Kim Johanna Inhyang (Department of Psychiatry Hanyang University Medical Center Seoul Korea) 홍윤철 (서울대학교)

저널정보: 대한예방의학회 예방의학회지 예방의학회지 제54권 제1호

발행연도: 2021.1

수록면: 37 - 45 (9page)

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Objectives: Bisphenol A (BPA) is used in the electrical, mechanical, medical, and food industries. Previous studies have suggested that BPA is an endocrine disruptor. Regulation of BPA has led to increased use of bisphenol F (BPF) and bisphenol S (BPS). However, few studies have investigated the associations of BPF and BPS with thyroid dysfunction in children. Our study investigated the associations of prenatal BPA and early childhood BPA, BPF, and BPS exposure with thyroid function in 6-year-old children. Methods: Prenatal BPA concentrations were measured during the second trimester of pregnancy in an established prospective birth cohort. We measured urinary BPA, BPF, and BPS concentrations and thyroid hormone levels (thyroid-stimulating hormone, total T3, and free T4) in 6-year-old children (n=574). We examined the associations between urinary bisphenol concentrations and percentage change of thyroid hormone concentrations using multivariate linear regression. We also compared thyroid hormone levels by dividing the cohort according to BPA, BPF, and BPS concentrations. Results: The associations between prenatal BPA and total T3 levels were statistically significant in all models, except for girls when using a crude model. The associations between urinary BPA and BPS concentrations and levels of all thyroid hormones were not statistically significant. However, we observed that lower free T4 levels (-1.94%; 95% confidence interval, -3.82 to -0.03) were associated with higher urinary BPF concentrations in girls only. Conclusions: Our findings identified significant associations between prenatal BPA exposure and total T3 levels in all children and between BPF exposure and free T4 levels in girls only.

#Bisphenol A #Bisphenol F #Bisphenol S #Child #Cohort studies #Thyroid hormones

참고문헌 (38)

참고문헌 신청

Roen EL / 2015 / Bisphenol A exposure and behavioral problems among inner city children at 7-9 years of age / Environ Res 142:739~745

Braun JM / 2017 / Associations of prenatal urinary bisphenol A concentrations with child behaviors and cognitive abilities / Environ Health Perspect 125(6):067008

Ghassabian A / 2018 / Concentrations of perfluoroalkyl substances and bisphenol A in newborn dried blood spots and the association with child behavior / Environ Pollut 243(Pt B):1629~1636

Li F / 2020 / Prenatal bisphenol A exposure, fetal thyroid hormones and neurobehavioral development in children at 2 and 4 years: a prospective cohort study / Sci Total Environ 722:137887

Lim YH / 2017 / Prenatal and postnatal bisphenol A exposure and social impairment in 4-year-old children / Environ Health 16(1):79

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이 논문의 저자 정보

Jang Yoonyoung

소속기관 Department of Preventive Medicine Seoul National University College of Medicine Seoul Korea