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논문 기본 정보

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학술저널
저자정보
Lee Ji-Hyang (Department of Allergy and Clinical Immunology Asan Medical Center University of Ulsan College of Me) Lee Chae Eun (Department of Allergy and Clinical Immunology Asan Medical Center University of Ulsan College of Me) Yoo Youngsang (Division of Pulmonary Allergy and Critical Care Medicine Department of Internal Medicine Gangneung) Shin Eunyong (Department of Allergy and Clinical Immunology Asan Medical Center University of Ulsan College of Me) An Jin (Department of Allergy and Clinical Immunology Asan Medical Center University of Ulsan College of Me) Park Seo Young (Department of Statistics and Data Science Korea National Open University Seoul Korea.) Song Woo-Jung (Department of Allergy and Clinical Immunology Asan Medical Center University of Ulsan College of Me) Kwon Hyouk-Soo (Department of Allergy and Clinical Immunology Asan Medical Center University of Ulsan College of Me) Cho You Sook (Department of Allergy and Clinical Immunology Asan Medical Center University of Ulsan College of Me) Moon Hee-Bom (Department of Allergy and Clinical Immunology Asan Medical Center University of Ulsan College of Me) Kim Tae-Bum (Department of Allergy and Clinical Immunology Asan Medical Center University of Ulsan College of Me)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.37 No.8
발행연도
2022.2
수록면
1 - 11 (11page)
DOI
10.3346/jkms.2022.37.e65

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Background: Angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine subtype 2 (TMPRSS2) are key proteins mediating viral entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although gene expressions of ACE2 and TMPRSS2 have been analyzed in various organs and diseases, their soluble forms have been less studied, particularly in asthma. Therefore, we aimed to measure circulating ACE2 and TMPRSS2 in the serum of asthmatics and examine their relationship with clinical characteristics. Methods: Clinical data and serum samples of 400 participants were obtained from an asthma cohort. The soluble ACE2 (sACE2) and soluble TMPRSS2 (sTMPRSS2) level was measured by enzyme-linked immunosorbent assay, and the values underwent a natural log transformation. Associations between sACE2 and TMPRSS2 levels and various clinical variables were analyzed. Results: The patients younger than 70 years old, those with eosinophilic asthma (eosinophils ≥ 200 cells/μL), and inhaled corticosteroids (ICS) non-users were associated with higher levels of sACE2. Blood eosinophils and fractionated exhaled nitric oxide levels were positively correlated with serum ACE2. In contrast, lower levels of sTMPRSS2 were noted in patients below 70 years and those with eosinophilic asthma, while no association was noted between ICS use and sTMPRSS2. The level of sTMPRSS2 also differed according to sex, smoking history, coexisting hypertension, and forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC) ratio. The proportion of sputum neutrophils was positively correlated with sTMPRSS2, while the FEV1/FVC ratio reported a negative correlation with sTMPRSS2. Conclusion: The levels of ACE2 and TMPRSS2 were differently expressed according to age, ICS use, and several inflammatory markers. These findings suggest variable susceptibility and prognosis of SARS-CoV-2 infection among asthmatic patients.
#Angiotensin-Converting Enzyme 2 #Transmembrane Protease Serine Subtype 2 #COVID-19 #Asthma

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