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논문 기본 정보

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학술저널
저자정보
Oh Young Bang (Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul) Eun Hee Kim (S&E bio Co. Ltd. Seoul Korea) Mi Jeong Oh (Translational and Stem Cell Research Laboratory on Stroke Samsung Medical Center Seoul Korea) Jaein Yoo (Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences and Technology (SAIHST) Sungkyunkwan University Seoul Korea) Gyun Sik Oh (S&E bio Co. Ltd. Seoul Korea) Jong-Won Chung (Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea) Woo-Keun Seo (Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea) Gyeong-Moon Kim (Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine) Myung-Ju Ahn (Division of Hematology-Oncology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine) Seong Wook Yang (Department of Systems Biology College of Life Science and Biotechnology Yonsei University Seoul Korea)
저널정보
대한뇌졸중학회 대한뇌졸중학회지 대한뇌졸중영문학회지 제25권 제2호
발행연도
2023.5
수록면
251 - 265 (15page)
DOI
10.5853/jos.2022.02327

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Background and Purpose This study aimed to evaluate whether extracellular-vesicle-incorporated microRNAs (miRNAs) are potential biomarkers for cancer-related stroke.Methods This cohort study compared patients with active cancer who had embolic stroke of unknown sources (cancer-stroke group) with patients with only cancer, patients with only stroke, and healthy individuals (control groups). The expression profiles of miRNAs encapsulated in plasma exosomes and microvesicles were evaluated using microarray and validated using quantitative real-time polymerase chain reaction. The XENO-QTM miRNA assay technology was used to determine the absolute copy numbers of individual miRNAs in an external validation cohort.Results This study recruited 220 patients, of which 45 had cancer-stroke, 76 were healthy controls, 39 were cancer controls, and 60 were stroke controls. Three miRNAs (miR-205-5p, miR-645, and miR-646) were specifically incorporated into microvesicles in patients with cancer-related stroke, cancer controls, and stroke controls. The area under the receiver operating characteristic curves of these three miRNAs were 0.7692–0.8510 for the differentiation of patients with cancer-stroke from cancer-controls and 0.8077–0.8846 for the differentiation of patients with cancer-stroke from stroke controls. The levels of several miRNAs were elevated in the plasma exosomes of patients with cancer, but were lower than those in plasma microvesicles. An in vivo study showed that systemic injection of miR-205-5p promoted the development of arterial thrombosis and elevation of D-dimer levels.Conclusion Stroke due to cancer-related coagulopathy was associated with deregulated expression of miRNAs, particularly microvesicle-incorporated miR-205-5p, miR-645, and miR-646. Further prospective studies of extracellular-vesicle-incorporated miRNAs are required to confirm the diagnostic role of miRNAs in patients with stroke and to screen the roles of miRNAs in patients with cancer.
#Cancer #Stroke #Coagulopathy #Biomarker #Extracellular vesicle #MicroRNA

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