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Medulloblastoma is considered one of the most threatening malignant brain tumors with an extremely high mortality rate in children. In the medulloblastoma, there are several genes and mutations found to work in an unregulated manner that works together to push the cells into a cancerous state. With the discovery of non-coding RNAs such as microRNAs (miRNAs), it has been shown that a different layer of gene regulations may be disrupted which would cause cancer. This fact led scientists to put their focus on the role of miRNAs in cancer. A mature miRNA contains a seed sequence which gives the miRNA to identify and attach to the interest mRNA; this attachment may lead degradation of mRNA or suppress of translation of the mRNA. The expression of miRNAs in medulloblastoma shows that some of these non-coding RNAs are overexpressed (OncomiRs) which help cells to proliferate and keep their stemness features. On the other hand, there are other forms of these miRNAs which normally inhibit cell proliferation and promote cell differentiation (tumor suppressor). These are down-regulated during cancer progression. In this systematic review, we attempted to gather several important studies on miRNAs’ role in medulloblastoma tumors and the importance of these non-coding RNAs in the future study of cancer. (J Cancer Prev 2019;24:79-90)
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참고문헌 (113)
참고문헌 신청
Bondy ML / 2008 / Brain tumor epidemiology: consensus from the Brain Tumor Epidemiology Consortium / Cancer 113:1953~1968
Prastawa M / 2004 / A brain tumor segmentation framework based on outlier detection / Med Image Anal 8:275~283
Zülch K / 1980 / Principles of the new World Health Organization (WHO)classification of brain tumors / Neuroradiology 19:59~66
DeAngelis LM / 2001 / Brain tumors / N Engl J Med 344:114~123
Carrie C / 1992 / Quality control of radiotherapeutic treatment of medulloblastoma in a multicentric study: the contribution of radiotherapy technique to tumour relapse / Radiother Oncol 24:77~81
Prastawa M / 2004 / A brain tumor segmentation framework based on outlier detection / Med Image Anal 8:275~283
Zülch K / 1980 / Principles of the new World Health Organization (WHO)classification of brain tumors / Neuroradiology 19:59~66
DeAngelis LM / 2001 / Brain tumors / N Engl J Med 344:114~123
Carrie C / 1992 / Quality control of radiotherapeutic treatment of medulloblastoma in a multicentric study: the contribution of radiotherapy technique to tumour relapse / Radiother Oncol 24:77~81
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