T Cell Microvilli: Finger-Shaped External Structures Linked to the Fate of T Cells

Hye-Ran Kim; Jeong-Su Park; Won-Chang Soh; Na-Young Kim; Hyun-Yoong Moon; Ji-Su Lee; Chang-Duk Jun

추천

검색

질문

자료유형: 학술저널

저자정보: Hye-Ran Kim (Gwangju Institute of Science and Technology (GIST)) Jeong-Su Park (Gwangju Institute of Science and Technology (GIST)) Won-Chang Soh (Gwangju Institute of Science and Technology (GIST)) Na-Young Kim (Gwangju Institute of Science and Technology (GIST)) Hyun-Yoong Moon (Gwangju Institute of Science and Technology (GIST)) Ji-Su Lee (Gwangju Institute of Science and Technology (GIST)) Chang-Duk Jun (Gwangju Institute of Science and Technology (GIST))

저널정보: 대한면역학회 Immune Network Immune Network Vol.23 No.1

발행연도: 2023.2

수록면: 23 - 36 (14page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Microvilli are outer membrane organelles that contain cross-linked filamentous actin. Unlike well-characterized epithelial microvilli, T-cell microvilli are dynamic similar to those of filopodia, which grow and shrink intermittently via the alternate actin-assembly and -disassembly. T-cell microvilli are specialized for sensing Ags on the surface of Ag-presenting cells (APCs). Thus, these finger-shaped microprotrusions contain many signaling-related proteins and can serve as a signaling platforms that induce intracellular signals. However, they are not limited to sensing external information but can provide sites for parts of the cell-body to tear away from the cell. Cells are known to produce many types of extracellular vesicles (EVs), such as exosomes, microvesicles, and membrane particles. T cells also produce EVs, but little is known about under what conditions T cells generate EVs and which types of EVs are released. We discovered that T cells produce few exosomes but release large amounsts of microvilli-derived particles during physical interaction with APCs. Although much is unanswered as to why T cells use the same organelles to sense Ags or to produce EVs, these events can significantly affect T cell fate, including clonal expansion and death. Since TCRs are localized at microvilli tips, this membrane event also raises a new question regarding long-standing paradigm in T cell biology; i.e., surface TCR downmodulation following T cell activation. Since T-cell microvilli particles carry T-cell message to their cognate partner, these particles are termed T-cell immunological synaptosomes (TISs). We discuss the potential physiological role of TISs and their application to immunotherapies.

#T cell #Microvilli #Extracellular vesicle #Molting

ABSTRACT
IMMUNOLOGICAL SYNAPSE AND TCR NANO AND MICROCLUSTERS
THE SURFACE OF T CELLS
T CELL MICROVILLI
EXTRACELLULAR VESICLES: COMPARISON OF EXOSOMES AND MICROVESICLES
T CELL MICROVILLI-DERIVED PARTICLES (TMPs)
PHYSIOLOGICAL FUNCTIONS OF TISs
APPLICATION OF TISs
FATE OF T CELLS AFTER THE RELEASE OF TISs
FUTURE DIRECTIONS AND CONCLUDING REMARKS
REFERENCES

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!