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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.12
- 수록면
- 462 - 480 (19page)
- DOI
- 10.7783/KJMCS.2022.30.6.462
이용수
DBpia Top 0.1%동일한 주제분류 기준으로최근 2년간 이용수 순으로 정렬했을 때
해당 논문이 위치하는 상위 비율을 의미합니다.
초록· 키워드
오류제보하기
Background: Plants are rich in phytochemicals, and their bioactive compounds have been employed in traditional medicine since ancient times. A variety of medicinal plant species and phytochemicals have been used to treat a wide range of chronic diseases, most notably, cancer.
Methods and Results: As the global prevalence of cancer increases, numerous investigations are being carried out to develop phytochemical-based medicines. For example, paclitaxel, camptothecin, vinca alkaloids, and podophyllotoxin are US Food and Drug Administration (FDA)-approved anticancer drugs derived from plants. However, plants contain only trace amounts of phytochemicals, which makes it difficult to supply them continuously. Moreover, their complicated structures hinder their ability to produce large quantities of chemicals for commercial use. Recently, researchers have developed a number of biotechnological platforms to enhance the production of phytochmicals.
Conclusions: In this review, we summarize the current status of four FDA-approved anticancer drugs derived from plants and provide plant biotechnology strategies, including synthetic biology, to facilitate their production.
Methods and Results: As the global prevalence of cancer increases, numerous investigations are being carried out to develop phytochemical-based medicines. For example, paclitaxel, camptothecin, vinca alkaloids, and podophyllotoxin are US Food and Drug Administration (FDA)-approved anticancer drugs derived from plants. However, plants contain only trace amounts of phytochemicals, which makes it difficult to supply them continuously. Moreover, their complicated structures hinder their ability to produce large quantities of chemicals for commercial use. Recently, researchers have developed a number of biotechnological platforms to enhance the production of phytochmicals.
Conclusions: In this review, we summarize the current status of four FDA-approved anticancer drugs derived from plants and provide plant biotechnology strategies, including synthetic biology, to facilitate their production.
목차
ABSTRACT
서언
1. FDA-승인 식물 유래 항암제와 생합성 경로
2. 식물 시스템에서 식물 유래 항암제 생산 증진 연구 동향
3. 식물 시스템에서 합성생물학을 이용한 생산 연구 동향과 전망
REFERENCES
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