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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 322 - 328 (7page)
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ObjectiveTo investigate the effect of genistein on the anticancer effects of chemotherapeutic agents, we examined the effectof a genistein and cisplatin combination on CaSki human cervical cancer cells. MethodsAfter the cervical cancer cells (HeLa cells, CaSki cells) had been cultured, cisplatin and genistein were added to theculture medium, and the cell activity was measured using MTT assay. The CaSki cells were cultured in a mediumcontaining cisplatin and genistein, and then, the cells were collected in order to measure p53, Bcl2, ERK, and caspase3 levels by western blotting. ResultsBoth the HeLa and CaSki cells had decreased cell viabilities when the cisplatin concentration was 10 μM or higher. When combined with genistein, the cell viabilities of the HeLa and CaSki cells decreased at cisplatin concentrations of8 μM and 6 μM, respectively. The administration of genistein increased the toxicity of cisplatin in the HeLa and CaSkicells. In the CaSki cells, the p-ERK1/2 level decreased by 37%, the p53 expression level increased by 304%, and thecleaved caspase 3 level increased by 115% in the cisplatin+genistein group compared to that in the cisplatin group. Bcl2 expression was reduced by 69% in the cisplatin+genistein group compared to that in the cisplatin group. ConclusionGenistein enhances the anticancer effect of cisplatin in CaSki cells, and can be used as a chemotherapeutic adjuvant toincrease the activity of a chemotherapeutic agent.
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참고문헌 (22)
참고문헌 신청
Bray F / 2018 / Global cancer statistics 2018 : GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries / CA Cancer J Clin 68:394~424
Kumar L / 2018 / Chemotherapy and targeted therapy in the management of cervical cancer / Curr Probl Cancer 42:120~128
Dasari S / 2014 / Cisplatin in cancer therapy : molecular mechanisms of action / Eur J Pharmacol 740:364~378
Wang D / 2005 / Cellular processing of platinum anticancer drugs / Nat Rev Drug Discov 4:307~320
Astolfi L / 2013 / Correlation of adverse effects of cisplatin administration in patients affected by solid tumours : a retrospective evaluation / Oncol Rep 29:1285~1292
Kumar L / 2018 / Chemotherapy and targeted therapy in the management of cervical cancer / Curr Probl Cancer 42:120~128
Dasari S / 2014 / Cisplatin in cancer therapy : molecular mechanisms of action / Eur J Pharmacol 740:364~378
Wang D / 2005 / Cellular processing of platinum anticancer drugs / Nat Rev Drug Discov 4:307~320
Astolfi L / 2013 / Correlation of adverse effects of cisplatin administration in patients affected by solid tumours : a retrospective evaluation / Oncol Rep 29:1285~1292
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