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논문 기본 정보

자료유형
학술저널
저자정보
Han Ah Lee (Departments of Internal Medicine Ewha Womans University College of Medicine) Young Chang (Department of Internal Medicine Soonchunhyang University College of Medicine) Pil Soo Sung (Department of Internal Medicine Seoul St. Mary’s Hospital College of Medicine The Catholic Universi) Eileen L. Yoon (Department of Internal Medicine Hanyang University College of Medicine) Hye Won Lee (Department of Internal Medicine Yonsei University College of Medicine) Jeong-Ju Yoo (Department of Internal Medicine Soonchunhyang University Bucheon Hospital) Young-Sun Lee (Department of Internal Medicine Korea University College of Medicine Seoul) Jihyun An (Department of Gastroenterology and Hepatology Hanyang University Guri Hospital) Do Seon Song (Department of Internal Medicine St. Vincent’s Hospital) Young Youn Cho (Department of Internal Medicine Chung-Ang University College of Medicine) Seung Up Kim (Department of Internal Medicine Yonsei University College of Medicine) Yoon Jun Kim (Department of Internal Medicine and Liver Research Institute Seoul National University College of M)
저널정보
대한간학회 Clinical and Molecular Hepatology Clinical and Molecular Hepatology 제28권 제3호
발행연도
2022.7
수록면
425 - 472 (48page)

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The global burden of chronic liver disease (CLD) is substantial. Due to the limited indication of and accessibility to antiviral therapy in viral hepatitis and lack of effective pharmacological treatment in nonalcoholic fatty liver disease, the beneficial effects of antidiabetics and non?antidiabetics in clinical practice have been continuously investigated in patients with CLD. In this narrative review, we focused on non-antidiabetic drugs, including ursodeoxycholic acid, silymarin, dimethyl- 4,4’-dimethoxy-5,6,5’,6’-dimethylenedixoybiphenyl-2,2’-dicarboxylate, L-ornithine L-aspartate, branched chain amino acids, statin, probiotics, vitamin E, and aspirin, and summarized their beneficial effects in CLD. Based on the antioxidant, anti-inflammatory properties, and regulatory functions in glucose or lipid metabolism, several non?antidiabetic drugs have shown beneficial effects in improving liver histology, aminotransferase level, and metabolic parameters and reducing risks of hepatocellular carcinoma and mortality, without significant safety concerns, in patients with CLD. Although the effect as the centerpiece management in patients with CLD is not robust, the use of these non-antidiabetic drugs might be potentially beneficial as an adjuvant or combined treatment strategy.

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