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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 244 - 248 (5page)
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초록· 키워드
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Due to the multifactorial and multisystemic nature of diabetes mellitus, it is often treated with a combination of therapeutic agents having different mode of action. Earlier, we have synthesized several organozinc complexes and evaluated their safety and antidiabetic properties in experimental type 2 diabetes mellitus (T2DM). More recently, we have synthesized a metformin-3-hydroxyflavone complex and studied its antidiabetic efficacy in experimental rats. In the present study, a new zinc-mixed ligand (metformin-3-hydroxyflavone) was synthesized, characterized by spectral studies and its antidiabetic properties was evaluated in HFD fed—low dose streptozotocin induced T2DM in rats. The hypoglycemic efficacy of the complex was evaluated through oral glucose tolerance test, homeostasis model assessment of insulin resistance, quantitative insulin sensitivity check index and by determining the status of important biochemical parameters. Oral administration of the complex at a concentration of 10 mg/kg body weight/rat/day for 30 days significantly improved the glucose homeostasis. The complex possesses significant antidiabetic properties relatively at a less concentration than metformin-3-hydroxyflavone complex in ameliorating hyperglycemia.
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참고문헌 (16)
참고문헌 신청
Thule PM / 2012 / Mechanisms of current therapies for diabetes mellitus type 2 / Adv Physiol Educ 36:275~283
Pandey A / 2011 / Alternative therapies useful in the management of diabetes: a systematic review / J Pharm Bioallied Sci 3:504~512
Cornard JP / 2003 / Comparison of the chelating power of hydroxyflavones / J Mol Struct 651(3):381~387
Turner RC / 1999 / Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group / JAMA 281:2005~2012
Yoshikawa Y / 2012 / Zinc complexes developed as metallopharmaceutics for treating diabetes mellitus based on the bio-medicinal inorganic chemistry / Curr Top Med Chem 12:210~218
Pandey A / 2011 / Alternative therapies useful in the management of diabetes: a systematic review / J Pharm Bioallied Sci 3:504~512
Cornard JP / 2003 / Comparison of the chelating power of hydroxyflavones / J Mol Struct 651(3):381~387
Turner RC / 1999 / Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group / JAMA 281:2005~2012
Yoshikawa Y / 2012 / Zinc complexes developed as metallopharmaceutics for treating diabetes mellitus based on the bio-medicinal inorganic chemistry / Curr Top Med Chem 12:210~218
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