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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.12
- 수록면
- 273 - 279 (7page)
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초록· 키워드
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The aim of this study was to investigate the mechanisms underlying apoptosis induced by a broussochalcone B (BCB) from Broussonetia papyrifera in HepG2 cells. The results showed that BCB treatment for 24 hr significantly inhibited cell viability in a dose-dependent manner, and induced apoptosis in HepG2 cells. More so, BCB treatment triggered the cleavage of caspase-8, -9, -3, poly (ADP-ribose) polymerase (PARP), increase of Bax level, and decrease of Bcl-2 expression. A general caspase inhibitor (z-VAD-fmk) blocked BCB-induced cell death. Furthermore, BCB treatment caused reactive oxygen species (ROS) production in a dose-dependent manner. In addition, an antioxidant N-acetylcysteine (NAC) blocked BCB-induced ROS production and cell death. Therefore, these results indicate that BCB-induced apoptosis is mediated by a caspase dependent pathway and ROS production in HepG2 cells.
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참고문헌 (7)
참고문헌 신청
강혜인 / 2010 / Primary 인체 전립선 암세포에서 Resveratrol의 Apoptosis 유도 효과 / 한국식품영양과학회지 39(8):1119~1125
박순영 / 2009 / 부추의 함황화합물이 인체 암세포 증식에 미치는 영향 / 한국식품영양과학회지 38(8):1003~1007
김나영 / 2008 / Butein의 Jurkat T 림포마 세포에서 발현되는 세포괴사 효과 / 생약학회지 39(2):150~154
최준혁 / 2009 / 로즈마리(Rosmarinus offcinalis L.) 분획물의 암세포에 대한 성장억제 및 세포사멸 유도 효과 / 한국식품영양과학회지 38(8):1008~1015
조병옥 / 2012 / 넓패 추출물이 HeLa 자궁암세포의 세포사멸에 미치는 영향 / 한국식품영양과학회지 41(7):901~906
박순영 / 2009 / 부추의 함황화합물이 인체 암세포 증식에 미치는 영향 / 한국식품영양과학회지 38(8):1003~1007
김나영 / 2008 / Butein의 Jurkat T 림포마 세포에서 발현되는 세포괴사 효과 / 생약학회지 39(2):150~154
최준혁 / 2009 / 로즈마리(Rosmarinus offcinalis L.) 분획물의 암세포에 대한 성장억제 및 세포사멸 유도 효과 / 한국식품영양과학회지 38(8):1008~1015
조병옥 / 2012 / 넓패 추출물이 HeLa 자궁암세포의 세포사멸에 미치는 영향 / 한국식품영양과학회지 41(7):901~906
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