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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.9
- 수록면
- 229 - 233 (5page)
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The anti-nociceptive effect of an ethanol extract and its various solvent fractions from Curcuma longa Linne ethanol extract was studied using the writhing test in mice. Different fractions by various solvent extraction from Curcuma longa Linne ethanol extract were administered orally 1 hr or time-course (0.5, 1, 2 and 5 hr) before intraperitoneal injection of acetic acid. After treatment with 30% ethanol extract and n-butanol fraction, CB-1, at a dose of 250 mg/kg, the significant writhing responses were 87.5 ± 13.4 (inhibition rate 31%, p<0.01) and 75.1 ± 11.1 (inhibition rate 41%, p<0.01) lower than the control group. At the dose of CB-1 50 mg/kg and 250 mg/kg, CB-1 showed a similar activity comparing to diclofenac of 10 mg/kg. A time-course experiment was performed, which involved oral administration of CB-1 (250 mg/kg) at 0, 0.5, 1, 2, and 5 hr before acetic acid intraperitoneal injection. The most effective time of CB-1 was 30 min before treatment and persisting until 2 hr. This study showed that Curcuma longa Linne has anti-nociceptive properties comparable with those of diclofenac, which suggests promise for the treatment of intractable visceral pain in humans. Major components of the active fraction are identified as curcumin, cyclocurcumin and demethoxycurcumin.
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참고문헌 (22)
참고문헌 신청
Gupta, S. C. / 2013 / Multitargeting by turmeric, the golden spice: From kitchen to clinic / Mol. Nutr. Food Res 57:1510~1528
Prasad, S / 2011 / Herbal Medicine / CRC Press
Lantz, R. C. / 2007 / The effect of extracts from ginger rhizome on inflammatory mediator production / Phytomedicine 14:123~128
Prasad, S. / 2014 / Curcumin, a component of golden spice: From bedside to bench and back / Biotech. Advances 32:1053~1064
Chandran, B. / 2012 / A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis / Phytother Res 26:1719~1725
Prasad, S / 2011 / Herbal Medicine / CRC Press
Lantz, R. C. / 2007 / The effect of extracts from ginger rhizome on inflammatory mediator production / Phytomedicine 14:123~128
Prasad, S. / 2014 / Curcumin, a component of golden spice: From bedside to bench and back / Biotech. Advances 32:1053~1064
Chandran, B. / 2012 / A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis / Phytother Res 26:1719~1725
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