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Induction of apoptotic cell death in human bladder cancer cells by ethanol extract of Zanthoxylum schinifolium leaf, through ROS-dependent inactivation of the PI3K/Akt signaling pathway
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Type
Academic journal
Author
Cheol Park (Dong-eui University) Eun Ok Choi (Dong-eui University) Hyun Hwangbo (Dong-eui University) Hyesook Lee (Dong-eui University) Jin-Woo Jeong (Nakdonggang National Institute of Biological Resources) Min Ho Han (National Marine Biodiversity Institute of Korea) Sung-Kwon Moon (Chung-Ang University)
Journal
The Korean Nutrition Society Nutrition Research and Practice Vol.16 No.3 KCI Accredited Journals SCIE
Published
2022.6
Pages
330 - 343 (14page)

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Induction of apoptotic cell death in human bladder cancer cells by ethanol extract of Zanthoxylum schinifolium leaf, through ROS-dependent inactivation of the PI3K/Akt signaling pathway
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Research history (6)

2022

Induction of apoptotic cell death in human bladder cancer cells by ethanol extract of Zanthoxylum schinifolium leaf, through ROS-dependent inactivation of the PI3K/Akt signaling pathway
Cheol Pa ,  k ,  Eun Ok Choi and others 10 Nutrition Research and Practice 2022.06 Academic journal
Induction of apoptotic cell death in human bladder cancer cells by ethanol extract of Zanthoxylum schinifolium leaf, through ROS-dependent inactivation of the PI3K/Akt signaling pathway
Cheol Pa ,  k ,  Eun Ok Choi and others 10 Nutrition Research and Practice 2022.06 Academic journal

2020

Ethanol extract of Hizikia fusiforme induces apoptotic cell death in B16F10 Mouse Melanoma Cells through ROS-Dependent Inhibition of the PI3K/Akt Signaling Pathway
Cheol Pa ,  k ,  Hyesook Lee and others 6 한국수산과학회 양식분과 학술대회 2020.07 Proceeding

2008

Pro-apoptotic Effects of Ethanol Extract of Hizikia fusiforme in Human Leukemic U937 Cells
Cheol Pa ,  k ,  Cheng-Yun Jin and others 5 한국생명과학회 심포지움 2008.10 Proceeding
Pro-apoptotic Effects of Ethanol Extract of Hizikia fusiforme in Human Leukemic U937 Cells
Cheol Pa ,  k ,  Cheng-Yun Jin and others 5 한국생명과학회 심포지움 2008.10 Proceeding

2005

Growth Inhibition of U937 Human Leukemia Cells by Aqueous Extract of Phellinus linteus through Induction of Apoptosis
Cheol Pa ,  k ,  Gi Young Kim and others 8 한국생명과학회 심포지움 2005.04 Proceeding
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Abstract· Keywords

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BACKGROUND/OBJECTIVES: Zanthoxylum schinifolium is traditionally used as a spice for cooking in East Asian countries. This study was undertaken to evaluate the anti-proliferative potential of ethanol extracts of Z. schinifolium leaves (EEZS) against human bladder cancer T24 cells.
MATERIALS/METHODS: Subsequent to measuring the cytotoxicity of EEZS, the anti-cancer activity was measured by assessing apoptosis induction, reactive oxygen species (ROS) generation, and mitochondrial membrane potential (MMP). In addition, we determined the underlying mechanism of EEZS-induced apoptosis through various assays, including Western blot analysis.
RESULTS: EEZS treatment concentration-dependently inhibited T24 cell survival, which is associated with apoptosis induction. Exposure to EEZS induced the expression of Fas and Fas-ligand, activated caspases, and subsequently resulted to cleavage of poly (ADP-ribose) polymerase. EEZS also enhanced the expression of cytochrome c in the cytoplasm by suppressing MMP, following increase in the ratio of Bax:Bcl-2 expression and truncation of Bid. However, EEZS-mediated growth inhibition and apoptosis were significantly diminished by a pan-caspase inhibitor. Moreover, EEZS inhibited activation of the phosphoinositide 3-kinase (PI3K)/Akt pathway, and the apoptosis-inducing potential of EEZS was promoted in the presence of PI3K/Akt inhibitor. In addition, EEZS enhanced the production of ROS, whereas N-acetyl cysteine (NAC), a ROS scavenger, markedly suppressed growth inhibition and inactivation of the PI3K/Akt signaling pathway induced by EEZS. Furthermore, NAC significantly attenuated the EEZS-induced apoptosis and reduction of cell viability.
CONCLUSIONS: Taken together, our results indicate that exposure to EEZS exhibits anticancer activity in T24 bladder cancer cells through ROS-dependent induction of apoptosis and inactivation of the PI3K/Akt signaling pathway.
#Apoptosis #reactive oxygen species #caspases #mitochondria #cytochrome c

Contents

ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
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