Influence of Panax ginseng formulation on skin microbiota: A randomized, split face comparative clinical study

Joon Hyuk Hou; Hyunjung Shin; Hyeji Shin; Yechan Kil; Da Hye Yang; Mi Kyeong Park; Wonhee Lee; Jun Yeup Seong; Seung Ho Lee; Hye Sun Cho; Soon Hong Yuk; Ki Yong Lee

Influence of Panax ginseng formulation on skin microbiota: A randomized, split face comparative clinical study

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Type: Academic journal

Author: Joon Hyuk Hou (Korea University) Hyunjung Shin (Korea Ginseng Corporation) Hyeji Shin (Korea University) Yechan Kil (Korea University) Da Hye Yang (Korea University) Mi Kyeong Park (Korea University) Wonhee Lee (Korea Ginseng Corporation) Jun Yeup Seong (Korea Ginseng Corporation) Seung Ho Lee (Korea Ginseng Corporation)

Journal: The Korean Society of Ginseng Journal of Ginseng Research Vol.46 No.2 KCI Candidated Journals SCIE

Published: 2022.3

Pages: 296 - 303 (8page)

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Influence of Panax ginseng formulation on skin microbiota: A randomized, split face comparative clinical study

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Background: Skin microbiota is important for maintenance of skin homeostasis; however, its disturbance may cause an increase in pathogenic microorganisms. Therefore, we aimed to develop a red ginseng formulation that can selectively promote beneficial bacteria.
Methods: The effects of red ginseng formulation on microorganism growth were analyzed by comparing the growth rates of Staphylococcus aureus, S. epidermidis, and Cutibacterium acnes. Various preservatives mixed with red ginseng formulation were evaluated to determine the ideal composition for selective growth promotion of S. epidermidis. Red ginseng formulation with selected preservative was loaded into a biocompatible polymer mixture and applied to the faces of 20 female subjects in the clinical trial to observe changes in the skin microbiome.
Results: Red ginseng formulation promoted the growth of S. aureus and S. epidermidis compared to fructooligosaccharide. When 1,2-hexanediol was applied with red ginseng formulation, only S. epidermidis showed selective growth. The analysis of the release rates of ginsenoside-Rg1 and -Re revealed that the exact content of Pluronic F-127 was around 11%. The application of hydrogel resulted in a decrease in C. acnes in all subjects. In subjects with low levels of S. epidermidis, the distribution of S. epidermidis was significantly increased with the application of hydrogel formulation and total microbial species of subjects decreased by 50% during the clinical trial.
Conclusion: We confirmed that red ginseng formulation with 1,2-hexanediol can help maintain skin homeostasis through improvement of skin microbiome.

#Clinical study #Korea red ginseng #Panax ginseng #Skin microbiota

ABSTRACT
1. Introduction
2. Materials and methods
3. Results and discussion
4. Conclusion
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