N-Acetyl cysteine mitigates histopathological changes and inflammatory genes expressions in the liver of cadmium exposed rats

Jalal Aala; Asghar Beigi Harchegani; Hanieh Akhlaghi Monsef; Zhaleh Mohsenifar; Pirooz Ebrahimi; Mohammad Reza Parvizi

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저자정보: Jalal Aala (AJA University of Medical Sciences) Asghar Beigi Harchegani (Shahid Beheshti University of Medical Sciences) Hanieh Akhlaghi Monsef (Islamic Azad University) Zhaleh Mohsenifar (Shahid Beheshti University of Medical Sciences) Pirooz Ebrahimi (University Scientific Education and Research Network) Mohammad Reza Parvizi (AJA University of Medical Sciences)

저널정보: 환경독성보건학회 Environmental Analysis Health and Toxicology Environmental Analysis Health and Toxicology Vol.36 No.4

발행연도: 2021.12

수록면: 21 - 30 (10page)

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This study aimed to consider the expression of Nrf2, NLRP3 and caspase 1 genes, as well as oxidative stress, and the protective role of N-acetyl cysteine (NAC) in the liver of rats treated with cadmium (Cd). Male rats were randomly divided into five groups including G1 (control), G2 (single dose of Cd), G3 (continuous dose of Cd), G4 (single dose of Cd + NAC), and G5 (continuous dose of Cd + NAC). Levels of malondialdehyde (MDA) and total antioxidant capacity (TAC) were measured. Expression of Nrf2, NLRP3 and caspase 1 genes was considered using RT-PCR. NAC treatments significantly improved TAC, but decreased MDA values in rats that exposed to continuous dose of Cd (p<0.05). Exposure to continuous dose of Cd caused a significant decrease in Nrf2 expression by 2.46-fold (p<0.001), but enhanced expression of NLRP3 and Caspase 1 genes by 3.13-fold and 3.16-fold), respectively (p<0.001). Compared to rats that treated to continuous dose of Cd, NAC supplementation enhanced the expression of Nrf2 by 1.67-fold (p<0.001) and reduced the expression of NLRP3 and Caspase 1 genes by 1.39-fold (p<0.001) and 1.58-fold (p<0.001), respectively. Down-regulation of Nrf2 and overexpression of NLRP3 and caspase 1 seems to be one of the main mechanisms of Cd toxicity on liver tissue. NAC protects liver tissue against Cd-induced oxidative injuries via enhancement of Nrf2 expression and reduction of NLRP3 and caspase 1 genes.

#Nrf2 #NLRP3 and caspase 1 #antioxidants #cadmium #N-Acetyl cysteine #oxidative stress

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