지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 223 - 230 (8page)
이용수
초록· 키워드
오류제보하기
Tumor necrosis factor alpha (TNF-α) is a principal regulator of inflammation and immunity. The proinflammatory properties of TNF-α can be attributed to its ability to activate the enzyme cytosolic phospholipase A₂ (cPLA₂), which generates potent inflammatory lipid mediators, eicosanoids. L-glutamine (Gln) plays physiologically important roles in various metabolic processes. We have reported that Gln has a potent anti-inflammatory activity via rapid upregulation of mitogen-activated protein kinases (MAPKs) phosphatase (MKP)-1, which preferentially dephosphorylates the key proinflammatory enzymes, p38 MAPK and cytosolic phospholipase A₂ (cPLA₂). In this study, we have investigated whether Gln could inhibit TNF-α-induced cPLA₂ activation. Gln inhibited TNF-α-induced increases in cPLA₂ phosphorylation in the lungs and blood levels of the cPLA₂ metabolites, leukotrine B4 (LTB4) (lipoxygenase metabolite) and prostaglandin E2 (PGE2) (cyclooxygenase metabolite). TNF-α increased p38 and cPLA₂ phosphorylation and blood levels of LTB4 and PGE2, which were blocked by the p38 inhibitor SB202190. Gln inhibited TNF-α-induced p38 and cPLA₂ phosphorylation and production of the cPLA₂ metabolites. Such inhibitory activity of Gln was no longer observed in MKP-1 small interfering RNA-pretreated animals. Our data indicate that Gln inhibited TNF-α-induced cPLA₂ phosphorylation through MKP-1 induction/p38 inhibition, and suggest that the utility of Gln in inflammatory diseases in which TNF-α plays a major role in their pathogenesis.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISSCUSSION
REFERENCES
참고문헌 (51)
참고문헌 신청
Albrecht J / 2010 / Roles of glutamine in neurotransmission / Neuron Glia Biol 6:263~276
Amores-Sanchez MI / 1999 / Glutamine, as a precursor of glutathione, and oxidative stress / Mol Genet Metab 67:100~105
Ayush O / 2016 / Glutamine up-regulates MAPK phosphatase-1 induction via activation of Ca2+-> ERK cascade pathway / Biochem Biophys Rep 7:10~19
Ayush O / 2013 / Glutamine suppresses dinitrofluorobenzene-induced contact dermatitis by deactivating p38 mitogen-activated protein kinase via induction of MAPK phosphatase-1 / J Invest Dermatol 133:723~731
Brondello JM / 1999 / Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation / Science 286:2514~2517
Amores-Sanchez MI / 1999 / Glutamine, as a precursor of glutathione, and oxidative stress / Mol Genet Metab 67:100~105
Ayush O / 2016 / Glutamine up-regulates MAPK phosphatase-1 induction via activation of Ca2+-> ERK cascade pathway / Biochem Biophys Rep 7:10~19
Ayush O / 2013 / Glutamine suppresses dinitrofluorobenzene-induced contact dermatitis by deactivating p38 mitogen-activated protein kinase via induction of MAPK phosphatase-1 / J Invest Dermatol 133:723~731
Brondello JM / 1999 / Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation / Science 286:2514~2517
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Updated Assessment of the Association of the XRCC1 Arg399Gln Polymorphism with Lung Cancer Risk in the Chinese Population
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Oral Glutamine Supplementation Reduces Radiotherapy-induced Esophagitis in Lung Cancer Patients
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Regulatory Roles of MAPK Phosphatases in Cancer
Immune Network
2016 .04
-
Upregulation of TNF-α by Triglycerides is Mediated by MEK1 Activation in Jurkat T Cells
대한의생명과학회지
2018 .09
-
Physicians Should Provide Shared Decision-Making for Anti-TNF Therapy to Inflammatory Bowel Disease Patients
Journal of Korean Medical Science
2017 .01
-
Efficacy of restarting anti-tumor necrosis factor α agents after surgery in patients with Crohn’s disease
Intestinal research
2018 .01
-
Effects of a Glutamine Enema on Anastomotic Healing in an Animal Colon Anastomosis Model
Annals of Coloproctology
2015 .01
-
Adjuvant treatment with a L-alanyl-L-glutamine supplementation in dogs with parvoviral enteritis
Journal of Biomedical and Translational Research
2023 .06
-
Impact of anti-tumor necrosis factor treatment on lipid profiles in Korean patients with ankylosing spondylitis
대한류마티스학회지
2024 .01
-
백출추출물이 TNF-α 유도 지방세포염증과 인슐린저항성 회복에 미치는 영향
Korean Journal of Acupuncture
2015 .01
-
Hb Murcia (β118(G19)His>Gln): A New Hemoglobin Variant Found in a Spanish Woman
Annals of Laboratory Medicine
2021 .09
-
Involvement of PI3K/AKT and MAPK Pathways for TNF-α Production in SiHa Cervical Mucosal Epithelial Cells Infected with Trichomonas vaginalis
Parasites, Hosts and Diseases
2015 .08
-
Plasma Levels of Tumor Necrosis Factor Superfamily Molecules Are Increased in Bipolar Disorder
Clinical Psychopharmacology and Neuroscience
2017 .08
-
Polymorphisms of Promoter Region of TNF-α Gene in Iranian Azeri Turkish Patients with Behçet’s Disease
Journal of Korean Medical Science
2017 .01
-
Effects of Amomum cadamomum Linne Extract on TNF-α-induced Inflammation and Insulin Resistance in 3T3-L1 Adipocytes
동의생리병리학회지
2016 .02
-
Tumor Necrosis Factor and Regulatory T Cells
Yonsei Medical Journal
2019 .01
-
강직척추염의 생물학적제제치료
대한의사협회지
2021 .01
-
Effects of Amomum cadamomum Linne Extract on TNF-α-induced Inflammation and Insulin Resistance in 3T3-L1 Adipocytes
동의생리병리학회지
2016 .01
-
Peripheral and Central Metabolites Affecting Depression, Anxiety, Suicidal Ideation, and Anger in Complex Regional Pain Syndrome Patients Using a Magnetic Resonance Spectroscopy: A Pilot Study
PSYCHIATRY INVESTIGATION
2018 .01
-
Is the Therapeutic Drug Monitoring of Anti-TNF Agents Necessary in Korean Inflammatory Bowel Disease Patients?
Gut and Liver
2017 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2022-510-000141703