지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Ankylosing spondylitis (AS) is a chronic inflammatory disease predominantly affecting the axial skeleton. AS treatment aims to reduce pain and inflammation and maintain functional capacity. Nonsteroidal anti-inflammatory drugs are the first-line treatment for those with active AS. While for peripheral arthritis, sulfasalazine or local glucocorticoid injection can be used, these are not recommended for axial symptoms. Twenty years ago, biological products that target the tumor necrosis factor (TNF) were developed. These have been approved for use in rheumatoid arthritis and AS. Since the introduction of these TNF inhibitors, the control of disease activity in AS has improved markedly. TNF inhibitors, including both anti-TNF-alpha monoclonal antibodies and recombinant TNF soluble receptors, can be considered for patients with persistently active disease despite nonsteroidal anti-inflammatory drug treatment. Recently, interleukin-17 inhibitors have also been approved for use in AS patients with insufficient responses to TNF inhibitors. Ongoing clinical trials are exploring the effect of Janus kinase inhibitors against AS. This review summarizes the current pharmaceutical treatment for AS, focusing on the biological products. Recommendations for AS management are also discussed in this review.
목차
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참고문헌 (13)
참고문헌 신청
Sieper J / 2009 / The Assessment of SpondyloArthritis international Society(ASAS)handbook : a guide to assess spondyloarthritis / Ann Rheum Dis 68(Suppl 2):ii1~ii44
van der Heijde D / 2017 / 2016 update of the ASAS-EULAR management recommendations for axial spondyloarthritis / Ann Rheum Dis 76:978~991
Ward MM / 2019 / 2019 Update of the American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network recommendations for the treatment of ankylosing spondylitis and nonradiographic axial spondyloarthritis / Arthritis Rheumatol 71:1599~1613
Machado PM / 2018 / Ankylosing Spondylitis Disease Activity Score(ASDAS) : 2018 update of the nomenclature for disease activity states / Ann Rheum Dis 77:1539~1540
Wang R / 2016 / Comparative efficacy of non-steroidal anti-inflammatory drugs in ankylosing spondylitis : a Bayesian network meta-analysis of clinical trials / Ann Rheum Dis 75:1152~1160
van der Heijde D / 2017 / 2016 update of the ASAS-EULAR management recommendations for axial spondyloarthritis / Ann Rheum Dis 76:978~991
Ward MM / 2019 / 2019 Update of the American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network recommendations for the treatment of ankylosing spondylitis and nonradiographic axial spondyloarthritis / Arthritis Rheumatol 71:1599~1613
Machado PM / 2018 / Ankylosing Spondylitis Disease Activity Score(ASDAS) : 2018 update of the nomenclature for disease activity states / Ann Rheum Dis 77:1539~1540
Wang R / 2016 / Comparative efficacy of non-steroidal anti-inflammatory drugs in ankylosing spondylitis : a Bayesian network meta-analysis of clinical trials / Ann Rheum Dis 75:1152~1160
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