Effects of a Glutamine Enema on Anastomotic Healing in an Animal Colon Anastomosis Model

Mani Habibi; Osman Zekai Oner; Mehmet Tahir Oruc; Nurullah Bulbuller; Sebahat Ozdem; Sukru Ozdemir; Arsenal Sezgin Alikanooglu; Rojbin Karakoyun; Ugur Dogan; Ayper Ongen; Umit Koc

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저자정보: Mani Habibi (Esenler Maternity and Child Health Hospi) Osman Zekai Oner (Antalya Training and Research Hospital) Mehmet Tahir Oruc (Antalya Training and Research Hospital) Nurullah Bulbuller (Akdeniz University) Sebahat Ozdem (Akdeniz University) Sukru Ozdemir (Karapınar State Hospital) Arsenal Sezgin Alikanooglu (Antalya Training and Research Hospital) Rojbin Karakoyun (Antalya Training and Research Hospital) Ugur Dogan (Antalya Training and Research Hospital) Ayper Ongen (Antalya Training and Research Hospital) Umit Koc (Antalya Training and Research Hospital)

저널정보: 대한대장항문학회 Annals of Coloproctology Annals of Coloproctolgy Vol.31 No.6

발행연도: 2015.1

수록면: 213 - 221 (9page)

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Purpose: Anastomotic leakage in colorectal surgery is a very important issue. Although many studies have shown the positive effects of enteral glutamine (Gln) on anastomotic healing, none has assessed the effects of administering Gln via an enema for anastomotic healing. To fill this study gap, this study investigated the intraluminal effect of administration of Gln enema on the healing of colonic anastomosis in a rat model. Methods: Thirty Wistar albino rats were divided into three groups containing 10 rats each and were subjected to distal left colon transection and anastomosis. Postoperatively, group I (the control group) was administered no treatment, group II was administered daily placebo enemas containing physiological saline, and group III was administered daily 2% L-Gln enemas. After sacrifice on postoperative day 5, anastomotic healing, burst pressure, tissue hydroxyproline levels, and histological parameters were measured, and group values were compared via statistical analysis. Results: Group III was found to have the highest mean bursting pressure and tissue hydroxyproline levels and the lowest mean ischemia score. While the values of these parameters were not found to differ significantly among the groups, the lack of significance may have been due to the limited number of subjects examined. Conclusion: Administration of a Gln enema may have a positive effect on anastomosis in terms of bursting pressure and histopathological parameters. Future research should examine administration of a preoperative Gln enema as a means of decreasing the traumatic effects of the enema and identifying its applicability in surgical practice.

참고문헌 (60)

참고문헌 신청

Attard JA / 2005 / The effects of systemic hypoxia on colon anastomotic healing : an animal model / Dis Colon Rectum 48:1460~1470

Parra-Membrives P / 2007 / Effect of pentoxifylline on the healing of ischemic colorectal anastomoses / Dis Colon Rectum 50:369~375

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Peeters KC / 2005 / Risk factors for anastomotic failure after total mesorectal excision of rectal cancer / Br J Surg 92:211~216

da Costa MA / 2003 / Oral glutamine and the healing of colonic anastomoses in rats / JPEN J Parenter Enteral Nutr 27:182~185

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