지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 664 - 669 (6page)
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초록· 키워드
오류제보하기
Breast cancer is one of the most frequently diagnosed cancers. Although biomarkers are continuously being discovered, few specific markers, rather than classification markers, representing the aggressiveness and invasiveness of breast cancer are known. In this study, we used samples from canine mammary tumors in a comparative approach. We subjected 36 fractions of both canine normal and mammary tumor plasmas to highperformance quantitative proteomics analysis. Among the identified proteins, LCAT was selectively expressed in mixed tumor samples. With further MRM and Western blot validation, we discovered that the LCAT protein is an indicator of aggressive mammary tumors, an advanced stage of cancer, possibly highly metastatic. Interestingly, we also found that LCAT is overexpressed in high-grade and lymph-node-positive breast cancer in silico data. We also demonstrated that LCAT is highly expressed in the sera of advanced-stage human breast cancers within the same classification. In conclusion, we identified a possible common plasma protein biomarker, LCAT, that is highly expressed in aggressive human breast cancer and canine mammary tumor.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Woolston C / 2015 / Breast cancer / Nature 527:S101
Hoag H / 2015 / Molecular biology : marked progress / Nature 527:S114~S115
Ulaner GA / 2016 / Molecular imaging of biomarkers in breast cancer / J Nucl Med 57(Suppl 1):53S~59S
Harris L / 2007 / American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer / J Clin Oncol 25:5287~5312
Geyer PE / 2017 / Revisiting biomarker discovery by plasma proteomics / Mol Syst Biol 13:942
Hoag H / 2015 / Molecular biology : marked progress / Nature 527:S114~S115
Ulaner GA / 2016 / Molecular imaging of biomarkers in breast cancer / J Nucl Med 57(Suppl 1):53S~59S
Harris L / 2007 / American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer / J Clin Oncol 25:5287~5312
Geyer PE / 2017 / Revisiting biomarker discovery by plasma proteomics / Mol Syst Biol 13:942
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