지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Lung cancer is the leading cause of cancer death in many countries, including Korea. The majority of patients are inoperable at the time of diagnosis because symptoms are typically manifested at an advanced stage. A recent large clinical trial demonstrated significant reduction in lung cancer mortality by using low dose computed tomography (LDCT) screening. A Korean multisociety collaborative committee systematically reviewed the evidences regarding the benefits and harms of lung cancer screening, and developed an evidence-based clinical guideline. There is highlevel evidence that annual screening with LDCT can reduce lung cancer mortality and all-cause mortality of high-risk individuals. The benefits of LDCT screening are modestly higher than the harms. Annual LDCT screening should be recommended to current smokers and ex-smokers (if less than 15 years have elapsed after smoking cessation) who are aged 55 to 74 years with 30 pack-years or more of smoking-history. LDCT can discover non-calcified lung nodules in 20 to 53% of the screened population, depending on the nodule positivity criteria. Individuals may undergo regular LDCT follow-up or invasive diagnostic procedures that lead to complications. Radiation-associated malignancies associated with repetitive LDCT, as well as overdiagnosis, should be considered the harms of screening. LDCT should be performed in qualified hospitals and interpreted by expert radiologists. Education and actions to stop smoking must be offered to current smokers. Chest radiograph, sputum cytology at regular intervals, and serum tumor markers should not be used as screening methods. These guidelines may be amended based on several large ongoing clinical trial results.
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
National Cancer Information Center / Cancer registry statistics 2012
정규원 / 2013 / Survival of Korean Adult Cancer Patients by Stage at Diagnosis, 2006-2010: National Cancer Registry Study / Cancer Research and Treatment 45(3):162~171
National Lung Screening Trial Research Team / 2011 / Reduced lung-cancer mortality with low-dose computed tomographic screening / N Engl J Med 365:395~409
Infante M / 2009 / A randomized study of lung cancer screening with spi-ral computed tomography : three-year results from the DANTE trial / Am J Respir Crit Care Med 180:445~453
Saghir Z / 2012 / The randomised Danish Lung Cancer Screening Trial : status after five annual screening rounds with low-dose CT / Thorax 67:296~301
정규원 / 2013 / Survival of Korean Adult Cancer Patients by Stage at Diagnosis, 2006-2010: National Cancer Registry Study / Cancer Research and Treatment 45(3):162~171
National Lung Screening Trial Research Team / 2011 / Reduced lung-cancer mortality with low-dose computed tomographic screening / N Engl J Med 365:395~409
Infante M / 2009 / A randomized study of lung cancer screening with spi-ral computed tomography : three-year results from the DANTE trial / Am J Respir Crit Care Med 180:445~453
Saghir Z / 2012 / The randomised Danish Lung Cancer Screening Trial : status after five annual screening rounds with low-dose CT / Thorax 67:296~301
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