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학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

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논문 기본 정보

자료유형
학술저널
저자정보
Yo Han Park (Seoul National University Bundang Hospital Seongnam) 김나영 (서울대학교) Young Kwang Shim (Seoul National Universtiy Bundang Hospital Seongnam) 최윤진 (고려대학교) Ryoung Hee Nam (Seoul National University Bundang Hospital Seongnam) Yoon Jeong Choi (Seoul National University Bundang Hospital Seongnam) Min Hee Ham (Seoul National University Bundang Hospital Seongnam) JI Hyung Suh (Seoul National University Bundang Hospital Seongnam) Sun Min Lee (Seoul National University Bundang Hospital Seongnam) 이창민 (경상대학교병원) Hyuk Yoon (Seoul National University Bundang Hospital Seongnam) 이혜승 (서울대학교) Dong Ho Lee (Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Gyeonggi-do)
저널정보
대한암예방학회 대한암예방학회지 대한암예방학회지 제20권 제4호
발행연도
2015.1
수록면
260 - 267 (8page)

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Background: Dextran sodium sulfate (DSS)-induced colitis mouse model is used for research of inflammatory bowel disease. The aim of this study was to establish the adequate conditions for DSS mice model, and to find useful tool to measure inflammation. Methods: The 2.5% DSS was administered to six male C57BL/6 mice and 4% DSS to eight mice at 5 or 9 weeks of age. Each group was consisted of 6 mice with control group in which vehicle was administered instead of DSS. The mice were sacrificed on the 7th day after DSS or vehicle administration. Body weight, diarrhea, and hematochezia were recorded daily. Disease activity index (DAI) score which was composed of body weight change, diarrhea, and hematochezia was measured every day. Colon length was measured after sacrifice and colon mucosal level of interleukin 1 beta (IL-1) was measured by ELISA assay. Histological score was compared between ascending and descending colon in the DSS group. Results: Colon length of five- and nine-week DSS group was significantly shorter than each control group but there was no statistical significance depending on DSS concentration or age. DAI score of 4% DSS group in nine-week was significantly higher than that five-week (P = 0.012) but there was no difference between 2.5% and 4% DSS group. The level of IL-1 in DSS mice was much higher than control group (P ＜ 0.01), but there was no difference among several DSS groups. The histological score was higher in the descending colon than in the ascending colon but there was no statistical difference between each pair of DSS groups. Conclusions: The 4% DSS mice in nine-week was adequate for DSS-induced colitis model. DAI score was useful tool and descending colon was more appropriate site for histological evaluation of colitis than ascending colon.

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참고문헌 (28)

참고문헌 신청
Ng SC / 2013 / Epidemiology and Natural History Task Force of the International Organization of Inflammatory Bowel Disease (IOIBD). Geographical variability and environmental risk factors in inflammatory bowel disease / Gut 62:630~649 google schola Sands BE / 2004 / From symptom to diagnosis: clinical distinctions among various forms of intestinal inflammation / Gastroenterology 126:1518~1532 google schola Mizoguchi A / 2012 / Animal models of inflammatory bowel disease / Prog Mol Biol Transl Sci 105:263~320 google schola Yan Y / 2009 / Temporal and spatial analysis of clinical and molecular parameters in dextran sodium sulfate induced colitis / PLoS One 4:e6073 google schola Ohkusa T / 1985 / Production of experimental ulcerative colitis in hamsters by dextran sulfate sodium and changes in intestinal microflora / Nihon Shokakibyo Gakkai Zasshi 82:1327~1336 google schola

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