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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 430 - 439 (10page)
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초록· 키워드
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Background/Aims: The current study aims to investigate the protective effects of Bifidobacterium infantis on the abnormal immune response to inflammatory bowel disease (IBD) in dextran sodium sulfate (DSS)-induced colitis. Methods: Eight-week-old BALB/c mice were separated into five groups at random (control, DSS, DSS+B9 [B. infantis 1×109 CFU], DSS+B8 [B. infantis 1×108 CFU], and DSS+B7 [B. infantis 1×107 CFU]). Colitis was induced by 5% DSS ad libitum for 7 days, at which time we assessed weight, the disease activity index (DAI) score, and the histological damage score. The nuclear transcription factor Foxp3 (a marker of Treg cells), cytokines interleukin-10 (IL-10) and transforming growth factor β1 (TGF-β1), and related proteins (programmed cell death ligand 1 [PD-L1] and programmed cell death 1 [PD-1]) were detected by an immunohistochemical method and Western blot. Results: B. infantis increased weight, decreased DAI scores and histological damage scores, increased the protein expression of Foxp3 (p<0.05) and cytokines IL-10 and TGF-β1 in mouse colon tissue (p<0.05), and increased the expression of PD-L1 in the treatment groups relative to that in the DSS group (p<0.05). The effect of B. infantis on Foxp3 and PD-L1 was dose dependent in the treatment groups (p<0.05). PD-L1 was positively correlated with Foxp3, IL- 10, and TGF-β1. Conclusions: In a mouse model of IBD, B. infantis can alleviate intestinal epithelial injury and maintain intestinal immune tolerance and thus may have potential therapeutic value for the treatment of immune damage in IBD.
목차
등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Kaplan GG / 2015 / The global burden of IBD : from 2015 to 2025 / Nat Rev Gastroenterol Hepatol 12:720~727
Ng SC / 2013 / Incidence and phenotype of inflammatory bowel disease based on results from the Asiapacific Crohn’s and colitis epidemiology study / Gastroenterology 145:158~165
Sarrabayrouse G / 2015 / Microbiotaspecific CD4CD8 alphaplaha Tregs : role in intestinal immune homeostasis and implications for IBD / Front Immunol 6:522
Maul J / 2005 / Peripheral and intestinal regulatory CD4+ CD25(high)T cells in inflammatory bowel disease / Gastroenterology 128:1868~1878
Kryczek I / 2016 / Inflammatory regulatory T cells in the microenvironments of ulcerative colitis and colon carcinoma / Oncoimmunology 5:e1105430
Ng SC / 2013 / Incidence and phenotype of inflammatory bowel disease based on results from the Asiapacific Crohn’s and colitis epidemiology study / Gastroenterology 145:158~165
Sarrabayrouse G / 2015 / Microbiotaspecific CD4CD8 alphaplaha Tregs : role in intestinal immune homeostasis and implications for IBD / Front Immunol 6:522
Maul J / 2005 / Peripheral and intestinal regulatory CD4+ CD25(high)T cells in inflammatory bowel disease / Gastroenterology 128:1868~1878
Kryczek I / 2016 / Inflammatory regulatory T cells in the microenvironments of ulcerative colitis and colon carcinoma / Oncoimmunology 5:e1105430
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