지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.6
- 수록면
- 135 - 141 (7page)
이용수
초록· 키워드
오류제보하기
Dysfunction of gut immune regulation is involved in mucosal damage in inflammatory bowel disease (IBD). However, there is still no efficacious immune-regulator for the treatment of IBD. Alloferon is a novel immune-modulatory peptide that was originally isolated from infected insects. It shows anti-inflammatory effects by the regulation of cytokine production by immune cells and their activities. Therefore, we investigated the effect of alloferon in a mouse model of colitis using dextran sulfate sodium (DSS). Colitis was induced by administration of DSS in drinking water for 7 consecutive days. It was confirmed by the presence of weight loss, diarrhea, hematochezia, and colon contraction. Alloferon was injected 4 days after DSS administration. We found that alloferon improved the pathogenesis of IBD based on the reduced disease activity index (DAI) and colon contraction. Edema, epithelial erosion, and immune cell infiltration were found in mice administered DSS, but the phenomena were reduced following alloferon treatment. The plasma level of IL-6, a classical pro-inflammatory cytokine in colitis, was also decreased by alloferon. Moreover, alloferon inhibited the TNF-α-induced degradation and phosphorylation of IκB in Colo205 colon cancer cells. Taken together, these results show that alloferon has anti-inflammatory effects and attenuates DSS-induced colitis.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (31)
참고문헌 신청
[학술지(정기간행물)] - Xavier, R. J. / 2007 / Unravelling the pathogenesis of inflammatory bowel disease / Nature 448 : 427 ~ 434
[학술지(정기간행물)] - Baumgart, D. C. / 2007 / Inflammatory bowel disease : clinical aspects established evolving therapies / Lancet 369 : 1641 ~ 1657
[학술지(정기간행물)] - Thia, K. T. / 2008 / An update on the epidemiology of inflammatory bowel disease in Asia / Am. J .Gastroenterol 103 : 3167 ~ 3182
[학술지(정기간행물)] - Yang, S. K. / 2008 / Epidemiology of inflammatory bowel disease in the Songpa-Kangdong district, Seoul, Korea, 1986-2005: a KASID study / Inflamm. Bowel. Dis 14 : 542 ~ 549
[학술지(정기간행물)] - Kraus, T. A. / 2004 / Failure to induce oral tolerance in Crohn's ulcerative colitis patients: possible genetic risk / Ann. N. Y. Acad. Sci 1029 : 225 ~ 238
[학술지(정기간행물)] - Baumgart, D. C. / 2007 / Inflammatory bowel disease : clinical aspects established evolving therapies / Lancet 369 : 1641 ~ 1657
[학술지(정기간행물)] - Thia, K. T. / 2008 / An update on the epidemiology of inflammatory bowel disease in Asia / Am. J .Gastroenterol 103 : 3167 ~ 3182
[학술지(정기간행물)] - Yang, S. K. / 2008 / Epidemiology of inflammatory bowel disease in the Songpa-Kangdong district, Seoul, Korea, 1986-2005: a KASID study / Inflamm. Bowel. Dis 14 : 542 ~ 549
[학술지(정기간행물)] - Kraus, T. A. / 2004 / Failure to induce oral tolerance in Crohn's ulcerative colitis patients: possible genetic risk / Ann. N. Y. Acad. Sci 1029 : 225 ~ 238
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The anti-oxidative and anti-inflammatory effect of Psoralea corylifolia on Ulcerative Colitis Induced by Dextran Sulfate Sodium in Mice
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UCI(KEPA) : I410-ECN-0101-2016-511-001754668