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The improving effect of Zizyphus jujube on dextran sulfate sodium-induced colitis in mice
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대추의 궤양성 대장염에 대한 개선 효과

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Type
Academic journal
Author
Myung, Noh-Yil (원광디지털대학교 한방건강학과)
Journal
대한본초학회 대한본초학회지(본초분과학회지) 대한본초학회지 제30권 제3호
Published
2015.1
Pages
35 - 40 (6page)

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The improving effect of Zizyphus jujube on dextran sulfate sodium-induced colitis in mice
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Abstract· Keywords

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Objectives : Zizyphus jujube (ZJ) has been used as a traditional medicine for various diseases. However, the inhibitory effect of ZJ on intestinal inflammation has not been fully understood, yet. The aim of this study is to investigate anti-colitis activity of ZJ in dextran sulfate sodium (DSS)-induced colitis mouse model. Methods : To investigate the protective effects of ZJ,the colitis mice were induced by drinking water containing 5% DSS for 7 days. Mice were randomized into groups receiving ZJ (500 mg/kg), sulfasalazine (SFZ) (150 mg/kg) as a positive control, or water as a negative control. We assayed the effects of ZJ on DSS-induced the clinical signs, measuring weight loss, colon length and disease activity index (DAI). Additionally, to find a possible explanation for the anti-inflammatory effects of ZJ, we evaluated the effects of ZJ on the production of prostaglandin $E_2$ ($PGE_2$) and expression of cyclooxygenase (COX)-2 in colitis tissue. Results : The results showed that mice treated with DSS showed considerable clinical signs, including weight loss, and reduced colon length. However, administration of ZJ significantly reduced the weight loss, shortens colon length, and improved DAI as clinical symptoms. Moreover, ZJ inhibited the $PGE_2$ production and COX-2 expression levels in DSS-treated colon tissues. Conclusions : Collectively, the findings of this study provide us with novel insights into the pharmacological actions of ZJ as a potential molecule for use in the treatment of intestinal inflammation including ulcerative colitis.
#Zizyphus jujube #Ulcerative Colitis #Dextran Sulfate Sodium #prostaglandin $E_2$ #Cyclooxygenase-2

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References (21)

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Han BH / 1993 / Sedative activity of aporphine and cyclopeptide alkaoids isolated from the seed of Zizyphus vulgaris var. Spinosus, and the fruits and stem bark of Zizyphus jujuba var. Inermis in mice / J Pharm Soc Korea 37(2):143~148 google schola Heo HJ / 2003 / Effects of oleamide on choline acetyltransferase and cognitive activities / Biosci Biotechnol Biochem 67(6):1284~1291 google schola Huang YL / 2008 / Effects of water-soluble carbohydrate concentrate from Chinese jujube on different intestinal and fecal indices / J Agric Food Chem 56(5):1734~1739 google schola Naftali T / 2008 / Ziziphus jujuba extract for the treatment of chronic idiopathic constipation: a controlled clinical trial / Digestion 78(4):224~228 google schola Hyams JS / 2000 / Inflammatory bowel disease / Pediatr Rev 21(9):291~295 google schola

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