지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 219 - 255 (37page)
이용수
초록· 키워드
오류제보하기
Cells undergo apoptosis mainly via two pathways—the mitochondrial pathway and the cytosolic pathway. It has been well documented that activation of the mitochondrial pathway promotes mitochondrial fragmentation and inhibition of mitochondrial fragmentation partly represses cell death. However, the mitochondrial events following activation of the cytosolic pathway are less understood. In this study, we treated Fas-activating antibody and found mitochondrial fragmentation without cell death in hippocampal primary neurons and HT-22 cell lines. Fas antibody treatment, in fact, promoted rapid activation of caspase-8, while executioner caspase-3 activation was not observed. Furthermore, blockage of caspase-8 efficiently prevented Fas antibody-induced mitochondrial fragmentation. These results suggest that the cytosolic pathway induced by death receptor activation promotes caspase-8-dependent mitochondrial fission.
목차
등록된 정보가 없습니다.
참고문헌 (38)
참고문헌 신청
Brookes PS / 2004 / Calcium, ATP, and ROS: a mitochondrial love-hate triangle / Am J Physiol Cell Physiol 287:C817~C833
Hoppins S / 2012 / Cell Biology. Mitochondrial dynamics and apoptosis--the ER connection / Science 337:1052~1054
Otera H / 2011 / Molecular mechanisms and physiologic functions of mitochondrial dynamics / J Biochem 149:241~251
Liesa M / 2013 / Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure / Cell Metab 17:491~506
Arnoult D / 2007 / Mitochondrial fragmentation in apoptosis / Trends Cell Biol 17:6~12
Hoppins S / 2012 / Cell Biology. Mitochondrial dynamics and apoptosis--the ER connection / Science 337:1052~1054
Otera H / 2011 / Molecular mechanisms and physiologic functions of mitochondrial dynamics / J Biochem 149:241~251
Liesa M / 2013 / Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure / Cell Metab 17:491~506
Arnoult D / 2007 / Mitochondrial fragmentation in apoptosis / Trends Cell Biol 17:6~12
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Nobiletin Exhibits Neuroprotective Effects against Mitochondrial Complex I Inhibition via Regulating Apoptotic Signaling
Experimental Neurobiology
2021 .01
-
Abnormal Mitochondria in a Non-human Primate Model of MPTP-induced Parkinson’s Disease: Drp1 and CDK5/p25 Signaling
Experimental Neurobiology
2019 .01
-
Mitochondrial Dysfunction in Parkinson's Disease
Experimental Neurobiology
2015 .01
-
‘세 부모 아이’ 대 ‘세 사람 아이’ : 영국의 미토콘드리아 기증 법령 분석
생명윤리
2015 .12
-
Overexpression of SIRT3 Suppresses Oxidative Stress-induced Neurotoxicity and Mitochondrial Dysfunction in Dopaminergic Neuronal Cells
Experimental Neurobiology
2021 .10
-
Glucose Levels in Culture Medium Determine Cell Death Mode in MPP+-treated Dopaminergic Neuronal Cells
Experimental Neurobiology
2015 .01
-
Pathways of Existence
International Digital Design Invitation Exhibition
2023 .12
-
The First Generation of iPSC Line from a Korean Alzheimer’s Disease Patient Carrying APP-V715M Mutation Exhibits a Distinct Mitochondrial Dysfunction
Experimental Neurobiology
2019 .01
-
선형가속기를 이용한 방사선조사에서 생쥐조직의 생화학적 변화
한국콘텐츠학회논문지
2016 .03
-
4IR-Pathway
International Digital Design Invitation Exhibition
2017 .05
-
The Complete Mitochondrial Genome Sequence of Rice Pest, the Korea Brown Planthopper (Nilaparvata lugens)
한국콘텐츠학회 ICCC 논문집
2018 .12
-
The Complete Mitochondrial Genome Sequence of a Rice Pest, the Guangdong Brown Planthopper (Nilaparvata lugens)
한국콘텐츠학회 ICCC 논문집
2018 .12
-
스포츠산업에 근거한 한국축구 FA컵 경기관람요인이 관람만족 및 재관람의도에 미치는 영향
한국엔터테인먼트산업학회논문지
2015 .09
-
[경상북도] 하고천 하천기본계획 하천시설 관리대장 : 부록, 구조물도
국립중앙도서관 연계자료
2016 .01
-
Cell.7
International Digital Design Invitation Exhibition
2018 .05
-
〈The Cell〉
International Digital Design Invitation Exhibition
2016 .12
-
노동경력과 가족경로 분석을 통해 본 청년기 연장(long youth)의 젠더 차이
한국여성학
2017 .06
-
Developmental Exposure to Di-(2-ethylhexyl) Phthalate Induces Cerebellar Granule Cell Apoptosis via the PI3K/AKT Signaling Pathway
Experimental Neurobiology
2018 .01
-
Study on the Dance Contents Production and Activation Plan using Drone
한국콘텐츠학회 ICCC 논문집
2016 .12
-
Social Death
International Digital Design Invitation Exhibition
2022 .07
이 논문의 저자 정보
최근 본 자료
댓글(0)
0