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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 197 - 205 (9page)
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We previously demonstrated that 1-methyl-4-phenylpyridinium (MPP+) causes caspase-independent, non-apoptotic death of dopaminergic (DA) neuronal cells. Here, we specifically examined whether change of glucose concentration in culture medium may play a role for determining cell death modes of DA neurons following MPP+ treatment. By incubating MN9D cells in medium containing varying concentrations of glucose (5~35 mM), we found that cells underwent a distinct cell death as determined by morphological and biochemical criteria. At 5~10 mM glucose concentration (low glucose levels), MPP+ induced typical of the apoptotic dell death accompanied with caspase activation and DNA fragmentation as well as cell shrinkage. In contrast, MN9D cells cultivated in medium containing more than 17.5 mM (high glucose levels) did not demonstrate any of these changes. Subsequently, we observed that MPP+ at low glucose levels but not high glucose levels led to ROS generation and subsequent JNK activation. Therefore, MPP+-induced cell death only at low glucose levels was significantly ameliorated following co-treatment with ROS scavenger, caspase inhibitor or JNK inhibitor. We basically confirmed the quite similar pattern of cell death in primary cultures of DA neurons. Taken together, our results suggest that a biochemically distinct cell death mode is recruited by MPP+ depending on extracellular glucose levels.
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참고문헌 (22)
참고문헌 신청
Dauer W / 2003 / Parkinson's disease:mechanisms and models / Neuron 39:889~909
Hartley A / 1994 / Complex I inhibitors induce dose-dependent apoptosis in PC12 cells: relevance to Parkinson’s disease / J Neurochem 63:1987~1990
Mochizuki H / 1994 / Apoptosis is induced by 1-methyl-4-phenylpyridinium ion (MPP+) in ventral mesencephalic-striatal co-culture in rat / Neurosci Lett 170:191~194
Tatton NA / 1997 / In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining / Neuroscience 77:1037~1048
Viswanath V / 2001 / Caspase-9activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridineinduced Parkinson's disease / J Neurosci 21:9519~9528
Hartley A / 1994 / Complex I inhibitors induce dose-dependent apoptosis in PC12 cells: relevance to Parkinson’s disease / J Neurochem 63:1987~1990
Mochizuki H / 1994 / Apoptosis is induced by 1-methyl-4-phenylpyridinium ion (MPP+) in ventral mesencephalic-striatal co-culture in rat / Neurosci Lett 170:191~194
Tatton NA / 1997 / In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining / Neuroscience 77:1037~1048
Viswanath V / 2001 / Caspase-9activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridineinduced Parkinson's disease / J Neurosci 21:9519~9528
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