지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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The cytotoxic effect and mechanism of Aralia elata were investigated in MDA-MB-231 human breast cancer cells. In this study, Aralia elata inhibited significantly the proliferation of MDA-MB-231 cells, and some typical apoptotic characteristics, such as nuclear fragmentation and chromatin condensation, were observed. In addition, flow cytometry analysis showed that Aralia elata increased the sub-G1 (apoptosis) population and apoptosis further confirmed by Annexin V-FITC and PI double staining. With respect to the mechanism underlying the induction of apoptosis, apoptosis-related mRNA and proteins were measured using a reverse transcription-polymerase chain reaction and western blot analysis. Aralia elata reduced anti-apoptotic Bcl-2 mRNA and protein levels, but pro-apoptotic Bax mRNA and protein expression were increased compared with the controls. Aralia elata also induced the cleavage of caspase-9 followed by the activation of caspase-3, resulting in the activation of poly-ADP-ribose polymerase. These results suggest that apoptotic activity of Aralia elata is probably modulated by a caspase-dependent cascade via the activation of intrinsic pathway. This is the first report to demonstrate the cytotoxic effect of Aralia elata on human breast cancer cells and to provide a possible mechanism for this activity.
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참고문헌 (38)
참고문헌 신청
Carmichael J. / 1987 / Evaluation of a tetrazolium-based semiautomated colorimetric assay : assessment of chemosensitivity testing / Cancer Res 47:936~942
Chung YS. / 2005 / Water extract of Aralia elata prevents cataractogenesis in vitro and in vivo / J. Ethnopharmacol 101:49~54
Cory S. / 2002 / The Bcl2 family : regulators of the cellular life-or-death switch / Nat. Rev, Cancer 2:647~656
Gouaze V. / 2004 / Overexpression of glucosylceramide synthase and P-glycoprotein in cancer cells selected for resistance to natural product chemotherapy / Mol. Cancer Ther 3:633~639
Gschwind M. / 1995 / Apoptotic cell death induces by β-amyloid1-42 peptide is cell type dependent / J. Neurochem 65:292~300
Chung YS. / 2005 / Water extract of Aralia elata prevents cataractogenesis in vitro and in vivo / J. Ethnopharmacol 101:49~54
Cory S. / 2002 / The Bcl2 family : regulators of the cellular life-or-death switch / Nat. Rev, Cancer 2:647~656
Gouaze V. / 2004 / Overexpression of glucosylceramide synthase and P-glycoprotein in cancer cells selected for resistance to natural product chemotherapy / Mol. Cancer Ther 3:633~639
Gschwind M. / 1995 / Apoptotic cell death induces by β-amyloid1-42 peptide is cell type dependent / J. Neurochem 65:292~300
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