지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,423 - 1,428 (6page)
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초록· 키워드
오류제보하기
Short telomeres are known as one of the risk factors for human cancers. The present study was conducted to evaluate the association between 6 polymorphisms, which were related with short telomere length in the Korean population, and lung cancer risk using 1,100 cases and 1,096 controls. Among the 6 polymorphisms, TERT rs2853669 was significantly associated with increased lung cancer risk under a recessive model (odds ratio [OR] = 1.38, 95% confidence interval [CI] = 1.05-1.81, P = 0.02). The effect of rs2853669 on lung cancer risk was significant in younger individuals (OR = 1.73, 95% CI = 1.18-2.54, P = 0.005) and adenocarcinoma (OR = 1.50, 95% CI = 1.07-2.07, P = 0.02). Our results suggest that a common functional promoter polymorphism, TERT rs2853669, may influence both telomere length and lung cancer risk in the Korean population.
목차
등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Blasco MA / 2005 / Telomeres and human disease: ageing, cancer and beyond / Nat Rev Genet 6:611~622
Campisi J / 2001 / Cellular senescence, cancer and aging: the telomere connection / Exp Gerontol 36:1619~1637
Gilley D / 2005 / Telomere dysfunction in aging and cancer / Int J Biochem Cell Biol 37:1000~1013
Alter BP / 2009 / Cancer in dyskeratosis congenita / Blood 113:6549~6557
Brouilette SW / 2007 / Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study / Lancet 369:107~114
Campisi J / 2001 / Cellular senescence, cancer and aging: the telomere connection / Exp Gerontol 36:1619~1637
Gilley D / 2005 / Telomere dysfunction in aging and cancer / Int J Biochem Cell Biol 37:1000~1013
Alter BP / 2009 / Cancer in dyskeratosis congenita / Blood 113:6549~6557
Brouilette SW / 2007 / Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study / Lancet 369:107~114
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