TP53 Codon 72 Polymorphisms and Lung Cancer Risk in the Bangladeshi Population

Chowdhury, Miraj Kobad; Moniruzzaman, Md; Al Emran, Abdullah; Mostafa, Mohammad Golam; Kuddus, Ruhul H; Uddin, M Aftab

추천

검색

자료유형: 학술저널

저자정보: Chowdhury, Miraj Kobad (Department of Genetic Engineering and Biotechnology, University of Dhaka) Moniruzzaman, Md (Department of Genetic Engineering and Biotechnology, University of Dhaka) Al Emran, Abdullah (Department of Genetic Engineering and Biotechnology, University of Dhaka) Mostafa, Mohammad Golam (Department of Histopathology, National Institute of Cancer Research and Hospital) Kuddus, Ruhul H (Department of Genetic Engineering and Biotechnology, University of Dhaka) Uddin, M Aftab (Department of Genetic Engineering and Biotechnology, University of Dhaka)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제8호

발행연도: 2015.1

수록면: 3,493 - 3,498 (6page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Objective: To assess associations between codon 72 polymorphisms (Pro or B and Arg or b alleles) of the TP53 gene and lung cancer risk among Bangladeshis. Materials and Methods: The distribution of the BB, Bb, and bb genotypes and the frequencies of the B and b alleles were determined by PCR-RFLP method using DNA extracted from leucocytes of 50 confirmed lung cancer patients and 50 age-matched controls and the data were analysed. Results: The ratio of BB, Bb, and bb genotypes were in Hardy-Weinberg equilibrium except for the male patients (${\chi}2=4.6$). The B allele is overrepresented among all patients (OR=2.0, p=0.02) and the female patients (OR=4.1, $p{\leq}0.01$) compared to the controls. The BB/bb ratio was also higher among the patients (OR=3.0, p=0.03). The relative risk of cancer for having BB over bb genotype was 1.8 (p=0.04) but no effect was observed for the Bb genotype. The B allele was overrepresented among patients with adenocarcinomas (OR=2.4, $p{\leq}0.01$) and squamous cell carcinomas (OR=2.7, $p{\leq}0.01$) over the controls but the difference was not significant for those with small cell lung carcinomas (OR=1.1, p=0.66). The B allele was overrepresented among patients age 50 or younger (OR=2.7, $p{\leq}0.01$), but not for older patients (OR=1.7, p=0.07), and among smokers compared to the controls (OR=1.8-10.0, $p{\leq}0.01-0.03$). However, no correlation between increasing pack-years and lung cancer was observed. Conclusions: The Pro/Pro (BB) genotype and the B allele are risk factors for lung cancer among Bangladeshis, particularly for people under age 50, women and smokers.

#Lung cancer #TP53 gene #codon 72 polymorphism #PCR-RFLP analysis #Bangladeshis

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!