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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,246 - 1,252 (7page)
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초록· 키워드
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The purpose of this study was to investigate the age-related NADPH oxidase (arNOX) activity in patients with age-related knee osteoarthritis (OA). Serum and cartilage arNOX activities were determined using an oxidized ferricytochrome C reduction assay. Fullthickness knee joint cartilages obtained through total knee replacement surgery were graded according to the Outerbridge (OB) classification. Radiographic severity of OA was determined on Knee X-rays according to the Kellgren-Lawrence (K/L) grading system. Cartilage β-galactosidase, HIF-1α, and GLUT-1 expression levels were evaluated as markers for tissue senescence, hypoxia, and glycolysis. Higher arNOX activities occurred with higher levels of cartilage β-galactosidase, HIF-1α, and GLUT-1 (P = 0.002). arNOX activity in cartilages with surface defects (OB grade II, III) was higher than in those without the defects (OB grade 0, I) (P = 0.012). Cartilage arNOX activity showed a positive correlation with serum arNOX activity (r = -0.577, P = 0.023). Serum arNOX activity was significantly higher in the OA subgroup with bilateral ROA than in the OA with no or unilateral ROA (2.449 ± 0.81, 2.022 ± 0.251 nM/mL, respectively, P = 0.019). The results of this study demonstrate that OA itself is not a cause to increase arNOX activities, however, arNOX hyperactivity is related to a high degree of cartilage degradation, and a high grade and extent of ROA in age-related OA.
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참고문헌 (23)
참고문헌 신청
Di Cesare PE / 2013 / Kelley’s textbook of rheumatology / Elsevier/Saunders :1617~1633
van der Kraan PM / 2012 / Osteoarthritis year 2012 in review: biology / Osteoarthritis Cartilage 20:1447~1450
Peansukmanee S / 2009 / Effects of hypoxia on glucose transport in primary equine chondrocytes in vitro and evidence of reduced GLUT1gene expression in pathologic cartilage in vivo / J Orthop Res 27:529~535
Loeser RF / 2011 / Aging and osteoarthritis / Curr Opin Rheumatol 23:492~496
Morré DJ / 1998 / The sulfonylurea-inhibited NADH oxidase activity of HeLa cell plasma membranes has properties of a protein disulfide-thiol oxidoreductase with protein disulfide-thiol interchange activity / J Bioenerg Biomembr 30:477~487
van der Kraan PM / 2012 / Osteoarthritis year 2012 in review: biology / Osteoarthritis Cartilage 20:1447~1450
Peansukmanee S / 2009 / Effects of hypoxia on glucose transport in primary equine chondrocytes in vitro and evidence of reduced GLUT1gene expression in pathologic cartilage in vivo / J Orthop Res 27:529~535
Loeser RF / 2011 / Aging and osteoarthritis / Curr Opin Rheumatol 23:492~496
Morré DJ / 1998 / The sulfonylurea-inhibited NADH oxidase activity of HeLa cell plasma membranes has properties of a protein disulfide-thiol oxidoreductase with protein disulfide-thiol interchange activity / J Bioenerg Biomembr 30:477~487
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