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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 735 - 740 (6page)
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Purpose: The aim of this study was to determine the relationship of hypoxia-inducible factor-2 (HIF-2α) and vascular endothelial growth factor (VEGF) with radiographic severity in primary osteoarthritis (OA) of the knee. Expression of these two factors in cartilagesamples from OA knee joints was examined at mRNA and protein levels.
Materials and Methods: Knee joints were examined using plain radiographs, and OA severity was assessed using the Kellgren and Lawrence (KL) grading system. Specimens were collected from 29 patients (31 knees) who underwent total knee replacementbecause of severe medial OA of the knee (KL grades 3 and 4), 16 patients who underwent knee arthroscopy (KL grade 2), and 5 patients with traumatic knees (KL grade 0). HIF-2α and VEGF expression was quantified by real-time polymerase chain reactionand western blotting.
Results: Cartilage degeneration correlated with the radiographic severity grade. OA severity, determined using the Mankin scale, correlated positively with the KL grade (r=0.8790, p<0.01), and HIF-2α and VEGF levels with the radiographic severity of knee OA (r=0.7001, p<0.05; r=0.6647, p<0.05).
Conclusion: In OA cartilage, HIF-2α and VEGF mRNA and protein levels were significantly and positively correlated. The expressionof both factors correlated positively with the KL grade. HIF-2α and VEGF, therefore, may serve as biochemical markers as well as potential therapeutic targets in knee OA.
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참고문헌 (16)
참고문헌 신청
Hunter DJ / 2006 / Osteoarthritis / BMJ 332:639~642
Sharma L / 2007 / Osteoarthritis: Diagnosis and Medical/Surgical Management / Wolters Kluwer/Lippincott Williams & Wilkins :3~26
Yang S / 2010 / Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction / Nat Med 16:687~693
Pfander D / 2001 / Vascular endothelial growth factor in articular cartilage of healthy and osteoarthritic human knee joints / Ann Rheum Dis 60:1070~1073
Saito T / 2010 / Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development / Nat Med 16:678~686
Sharma L / 2007 / Osteoarthritis: Diagnosis and Medical/Surgical Management / Wolters Kluwer/Lippincott Williams & Wilkins :3~26
Yang S / 2010 / Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction / Nat Med 16:687~693
Pfander D / 2001 / Vascular endothelial growth factor in articular cartilage of healthy and osteoarthritic human knee joints / Ann Rheum Dis 60:1070~1073
Saito T / 2010 / Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development / Nat Med 16:678~686
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