지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 760 - 768 (9page)
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초록· 키워드
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Purpose: To compare differentially expressed genes (DEGs) mediating osteoarthritis (OA) in knee cartilage and in normal kneecartilage in a rat model of OA and to identify their impact on molecular pathways associated with OA. Materials and Methods: A gene expression profile was downloaded from the Gene Expression Omnibus database. Analysis ofDEGs was carried out using GEO2R. Enrichment analyses were performed on the Gene Ontology (GO) and Kyoto Encyclopedia ofGenes and Genomes pathway using the Search Tool for the Retrieval of Interacting Genes database (http://www.string-db.org/). Subsequently, the regulatory interaction network of OA-associated genes was visualized using Cytoscape software (version 3.4.0;www.cytoscape.org). Results: In the gene expression profile GSE103416, a total of 99 DEGs were identified. Among them, 76 DEGs (76.77%) were overexpressed,and the remaining 23 DEGs (23.23%) were underexpressed. GO and pathway enrichment analyses of target geneswere performed. Using gene-gene interaction network analysis, relevant core genes, including MET, UBB, GNAI3, and GNA13,were shown to hold a potential relationship with the development of OA in cartilage. Using quantitative real-time PCR, the Gna13/cGMP-PKG signaling pathway was identified as a potential research target for therapy and for further understanding the developmentof OA. Conclusion: The results of the present study provide a comprehensive understanding of the roles of DEGs in knee cartilage in relationto the development of OA.
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참고문헌 (31)
참고문헌 신청
Hussain SM / 2016 / Knee osteoarthritis: a review of management options / Scott Med J 61:7~16
Ayral X / 2005 / Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis -- results of a 1 year longitudinal arthroscopic study in 422 patients / Osteoarthritis Cartilage 13:361~367
Lohmander LS / 1999 / Changes in joint cartilage aggrecan after knee injury and in osteoarthritis / Arthritis Rheum 42:534~544
Brandt KD / 2008 / Etiopathogenesis of osteoarthritis / Rheum Dis Clin North Am 34:531~559
Lotz MK / 2010 / New developments in osteoarthritis. Posttraumatic osteoarthritis: pathogenesis and pharmacological treatment options / Arthritis Res Ther 12:211
Ayral X / 2005 / Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis -- results of a 1 year longitudinal arthroscopic study in 422 patients / Osteoarthritis Cartilage 13:361~367
Lohmander LS / 1999 / Changes in joint cartilage aggrecan after knee injury and in osteoarthritis / Arthritis Rheum 42:534~544
Brandt KD / 2008 / Etiopathogenesis of osteoarthritis / Rheum Dis Clin North Am 34:531~559
Lotz MK / 2010 / New developments in osteoarthritis. Posttraumatic osteoarthritis: pathogenesis and pharmacological treatment options / Arthritis Res Ther 12:211
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