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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.7 No.3
- 발행연도
- 2015.1
- 수록면
- 276 - 282 (7page)
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Purpose: Nasal polyps are associated with chronic inflammation of the mucous membranes in the nose and paranasal sinuses and involved in extracellular matrix (ECM) accumulation. Delphinidin promotes ECM degradation in hepatitis and cardiac fibrosis. The aims of this study were to examine the inhibitory effect of delphinidin on TGF-β1-induced myofibroblast differentiation and ECM accumulation, and to determine the underlying mechanisms in nasal polyp-derived fibroblasts (NPDFs). Methods: NPDFs were stimulated with TGF-β1, with or without delphinidin, and the expression levels of α-SMA, fibronectin, and collagen type I were determined by RT-PCR, Western blot analysis, and collagen assay. The expression of α-SMA protein was measured by immunocytochemical staining. Mitogen-activated protein kinase and NF-κB activation induced by TGF-β1 were determined by Western blot analysis. The transcriptional activity of NF-κB was measured by luciferase assay. Results: The expression levels of α-SMA, fibronectin, and collagen type I increased in TGF-β1-stimulated NPDFs. In TGF-β1-induced NPDFs, delphinidin inhibited the expression of α-SMA, fibronectin, and collagen. Inhibitors of MAPK and NF-κB blocked the expression of α-SMA, fibronectin, and collagen type I. Delphinidin suppressed the activation of MAPK and NF-κB induced by TGF-β1 stimulation. Conclusions: These results suggest that delphinidin may inhibit TGF- β1-induced myofibroblast differentiation and ECM production through the MAPK/NF-κB signaling pathway in NPDFs.
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참고문헌 (26)
참고문헌 신청
Pawankar R / 2003 / Nasal polyposis: an update: editorial review / Curr Opin Allergy Clin Immunol 3:1~6
Chaaban MR / 2013 / Epidemiology and differential diagnosis of nasal polyps / Am J Rhinol Allergy 27:473~478
Rinia AB / 2007 / Nasal polyposis: a cellular-based approach to answering questions / Allergy 62:348~358
Kendall RT / 2014 / Fibroblasts in fibrosis: novel roles and mediators / Front Pharmacol 5:123
Haruna S / 2004 / Histopathological features of nasal polyps with asthma association: an immunohistochemical study / Am J Rhinol 18:165~172
Chaaban MR / 2013 / Epidemiology and differential diagnosis of nasal polyps / Am J Rhinol Allergy 27:473~478
Rinia AB / 2007 / Nasal polyposis: a cellular-based approach to answering questions / Allergy 62:348~358
Kendall RT / 2014 / Fibroblasts in fibrosis: novel roles and mediators / Front Pharmacol 5:123
Haruna S / 2004 / Histopathological features of nasal polyps with asthma association: an immunohistochemical study / Am J Rhinol 18:165~172
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