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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1 - 6 (6page)
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Nasal polyposis is a multi-factorial disease associated with chronic inflammation of the paranasal sinuses. Myofibroblast differentiation and extracellular matrix (ECM) accumulation are involved in the pathogenesis of nasal polyposis. Epigenetics, DNA methylation, and chromatin modifications are critical for generating cellular diversity and for maintaining distinct gene expression profiles. Based on our recent study that evaluated the inhibitory effect of Trichostatin A on myofibroblast differentiation in nasal polyposis, we hypothesized that HDAC inhibition is associated with myofibroblast differentiation and extracellular matrix accumulation in nasal polyposis and suggested that Trischostatin A may be useful as an inhibitor of nasal polyp growth and thus has potential to be used as a novel treatment option for nasal polyposis. In this review, we present general concept of epigenetics and results of recent research that elucidate the role of epigenetics in the pathogenesis of nasal polyps.
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참고문헌 (26)
참고문헌 신청
Bird A / 2007 / Perceptions of epigenetics / Nature 447:396~398
Fraga MF / 2005 / Epigenetic differences arise during the lifetime of monozygotic twins / Proceedings of the National Academy of Sciences of the United States of America 102:10604~10609
Kaminsky ZA / 2009 / DNA methylation profiles in monozygotic and dizygotic twins / Nature genetics 41:240~245
Portela A / 2010 / Epigenetic modifications and human disease / Nature Biotechnology 28:1057~1068
Straussman R / 2009 / Developmental programming of CpG island methylation profiles in the human genome / Nature Structural & Molecular biology 16:564~571
Fraga MF / 2005 / Epigenetic differences arise during the lifetime of monozygotic twins / Proceedings of the National Academy of Sciences of the United States of America 102:10604~10609
Kaminsky ZA / 2009 / DNA methylation profiles in monozygotic and dizygotic twins / Nature genetics 41:240~245
Portela A / 2010 / Epigenetic modifications and human disease / Nature Biotechnology 28:1057~1068
Straussman R / 2009 / Developmental programming of CpG island methylation profiles in the human genome / Nature Structural & Molecular biology 16:564~571
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