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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 63 - 69 (7page)
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초록· 키워드
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A clinical practice-based observational study was performed to compare the outcome of alendronate (ALN) and teriparatide (TPTD) treatment among Japanese postmenopausal women with a history of fragility fractures. Sixty-one Japanese postmenopausal women with a history of fragility fractures were treated with ALN (35 mg weekly, n ¼ 32) or TPTD (20 mg daily, n ¼ 29) for 2 years in our outpatient clinic. Alfacalcidol (1 mg daily) was combined with ALN. The lumbar spine or total hip bone mineral density (BMD) was measured using dual energy X-ray absorptiometry, and bone turnover markers were monitored. ALN decreased the urinary levels of cross-linked N-terminal telopeptides of type I collagen (NTX) (38.3% after 3 months) and the serum levels of alkaline phosphatase (ALP) (25.7% at 24 months), whereas TPTD increased the serum levels of intact procollagen type 1 N-terminal propeptide (P1NP) and ALP (79% and 14.1%, respectively at 24 months). Both ALN and TPTD increased the lumbar spine BMD (8.8% and 15.9%, respectively) and sustained the total hip BMD at 24 months. One patient treated with ALN experienced vertebral fractures, and one patient treated with TPTD experienced a nonvertebral fracture. These results confirmed the differential effects of ALN and TPTD on bone turnover and the greater effect of TPTD on the BMD among Japanese postmenopausal women with a history of fragility fractures.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Black DM / 1996 / Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures / Lancet 348:153~141
Cummings SR / 1998 / Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the fracture intervention trial / J Am Med Assoc 280:2077~2082
Lilly / Highlights of prescribing information
Neer RM / 2001 / Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis / N Engl J Med 344:1434~1441
Body JJ / 2002 / A randomized double-blind trial to compare the efficacy of teriparatide [recombinant human parathyroid hormone (1-34)] with alendronate in postmenopausal women with osteoporosis / J Clin Endocrinol Metab 87:4528~4535
Cummings SR / 1998 / Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the fracture intervention trial / J Am Med Assoc 280:2077~2082
Lilly / Highlights of prescribing information
Neer RM / 2001 / Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis / N Engl J Med 344:1434~1441
Body JJ / 2002 / A randomized double-blind trial to compare the efficacy of teriparatide [recombinant human parathyroid hormone (1-34)] with alendronate in postmenopausal women with osteoporosis / J Clin Endocrinol Metab 87:4528~4535
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