지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
오류제보하기
Background: Bisphosphonates (BPs) are the most commonly used anti-osteoporotic drugs, which have been proven to reduce the risk of osteoporotic fractures. However, use of BPs, particularly for long periods of time, is associated with an increased risk of atypical femoral fracture (AFF). Healing of BP-associated AFF is usually delayed because of suppressed bone turnover. Teriparatide (TPTD), a recombinant form of parathyroid hormone (PTH), enhances bone healing in patients with delayed healing or non-union.
Methods: In this study, we summarized and performed a systemic review of the published literature on treatment of AFF using TPTD. Results: Although there is a lack of level 1 studies on the evidence of TPTD in promoting bone union in AFFs, this systemic review of the available literature revealed that TPTD works positively in AFFs, and we put together the evidence that TPTD is a viable treatment option for enhancing fracture healing in AFFs. Conclusions: While anecdotal evidence of beneficial effects of TPTD on fracture healing offer limited guidance for clinical decision making, a better understanding of the role of TPTD in fracture healing may be elucidated with future prospective trials.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Alkhiary YM / 2005 / Enhancement of experimental fracture-healing by systemic administration of recombinant human parathyroid hormone(PTH 1-34) / J Bone Joint Surg Am 87 : 7
Aspenberg P / 2010 / Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postme
Bostrom MP / 2000 / Parathyroid hormone-related protein analog RS-66271 is an effective therapy for impaired bone healing in rabbits on corticosteroid therapy / Bone 26 : 43
Currey J / 2005 / Structural heterogeneity in bone: good or bad? / J Musculoskelet Neuronal Interact 5 : 317 ~
Currey JD / 2005 / Bone architecture and fracture / Curr Osteoporos Rep 3 : 52 ~ 56
Aspenberg P / 2010 / Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postme
Bostrom MP / 2000 / Parathyroid hormone-related protein analog RS-66271 is an effective therapy for impaired bone healing in rabbits on corticosteroid therapy / Bone 26 : 43
Currey J / 2005 / Structural heterogeneity in bone: good or bad? / J Musculoskelet Neuronal Interact 5 : 317 ~
Currey JD / 2005 / Bone architecture and fracture / Curr Osteoporos Rep 3 : 52 ~ 56
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