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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 148 - 156 (9page)
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Purpose: Atypical femoral fracture (AFF), periprosthetic femoral fracture (PPFF) and femoral nonunion (FNU) are recalcitrant challenges for orthopedic surgeons. Teriparatide (TPTD) had been demonstrated to have anabolic effects on bone in various studies. We postulated that adjuvant TPTD after operation would enhance biologic stimulation for bone formation. We investigated (1) whether the adjuvant TPTD could achieve satisfactory union rate of surgically challenging cases such as displaced AFF, PPFF and FNU; (2) whether the adjuvant TPTD could promote development of abundant callus after surgical fixation; (3) whether the adjuvant TPTD had medically serious adverse effects.
Materials and Methods: Thirteen patients who agreed to off label use of TPTD in combination of operation were included in this retrospective case series. Median patients’ age was 68.7 years, and there were three male and ten female patients. Their diagnoses were nonunion in six patients and acute fracture in seven. Medical records and radiographic images were reviewed.
Results: Twelve of thirteen fractures were united both clinically and radiologically within a year after adjuvant TPTD. Union completed radiologically median 5.4 months and clinically 5.7 months after the medication, respectively. Callus appeared abundantly showing median 1.4 of fracture healing response postoperatively. There was no serious adverse reaction of medication other than itching, muscle cramp, or nausea.
Conclusion: Even appropriate surgical treatment is a mainstay of treatment for AFF, PPFF, and FNU, the current report suggested that adjuvant TPTD combined with stable fixation results in satisfactory outcome for the challenging fractures of femur.
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등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Kang JS / 2014 / Atypical femoral fractures after anti-osteoporotic medication : a Korean multicenter study / Int Orthop 38:1247~1253
Finkemeier CG / 2002 / Treatment of femoral diaphyseal nonunions / Clin Orthop Relat Res :398223~398234
Holder N / 2014 / Outcomes following surgical treatment of periprosthetic femur fractures : a single centre series / Can J Surg 57:209~213
Weil YA / 2011 / The outcome of surgically treated femur fractures associated with long-term bisphosphonate use / J Trauma 71:186~190
Gelalis ID / 2012 / Diagnostic and treatment modalities in nonunions of the femoral shaft : a review / Injury 43:980~988
Finkemeier CG / 2002 / Treatment of femoral diaphyseal nonunions / Clin Orthop Relat Res :398223~398234
Holder N / 2014 / Outcomes following surgical treatment of periprosthetic femur fractures : a single centre series / Can J Surg 57:209~213
Weil YA / 2011 / The outcome of surgically treated femur fractures associated with long-term bisphosphonate use / J Trauma 71:186~190
Gelalis ID / 2012 / Diagnostic and treatment modalities in nonunions of the femoral shaft : a review / Injury 43:980~988
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