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논문 기본 정보

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학술저널
저자정보
Yoshiaki Yamanaka (Department of Orthopaedic Surgery University of Occupational and Environmental Health Japan) Kunitaka Menuki (Department of Orthopaedic Surgery University of Occupational and Environmental Health Japan) Yukichi Zenke (Department of Orthopaedic Surgery University of Occupational and Environmental Health Japan) Satoshi Ikeda (Department of Orthopaedic Surgery Ken-Ai Memorial Hospital Fukuoka Japan) Eiji Hatakeyama (Department of Orthopaedic Surgery Fukuoka Shin Mizumaki Hospital Fukuoka Japan) Kimiaki Kawano (Department of Orthopaedic Surgery Ashiya Central Hospital Fukuoka Japan) Satoshi Nishida (Department of Orthopaedic Surgery Social Insurance Nogata Hospital Nogata Japan) Hiroaki Tanaka (Department of Orthopaedic Surgery Kurate Hospital Kurate Japan) Keiichi Yumisashi (Department of Emergency Medicine University of Occupational and Environmental Health Japan) Akinori Sakai (Department of Orthopaedic Surgery University of Occupational and Environmental Health Japan)
저널정보
대한골다공증학회 Osteoporosis and Sarcopenia Osteoporosis and Sarcopenia Vol.5 No.4
발행연도
2019.1
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116 - 121 (6page)

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Objectives: To assess the vitamin D status in postmenopausal women with osteoporotic fractures, determine its concentration by fracture site at the clinical setting, and compare the proportion of vitamin D deficiency with that reported in literature. Methods: The prospective study included 317 postmenopausal women with osteoporotic fractures who were treated consecutively from 2016 to 2018. After obtaining informed consent for participation in the seamless treatment of osteoporosis against fractures study, which is our initiative to prevent secondary osteoporotic fractures, we registered the patients, examined bone mineral density (BMD) at the unfractured femoral neck and lumbar spine, serum 25-hydroxyvitamin D (25(OH)D) concentration, blood chemistry, and bone turnover markers. Results: The mean age of the patients was 80.7 years. Moreover, 78% of patients of all fractures had 25(OH)D concentration < 20 ng/mL, whereas 12% of patients had 25(OH)D concentration 30 ng/mL 25(OH)D concentration in hip fractures was significantly lower than that in vertebral or distal radius fractures (P < 0.05). Multiple regression analysis revealed that 25(OH)D concentration is significantly associated with femoral neck BMD (b ¼ 0.16; 95% confidence interval [CI], 0.78e12.17, P ¼ 0.03) and serum albumin concentration (b ¼ 0.21; 95% CI, 0.62e2.96, P < 0.001) in patients with 25(OH)D concentration < 30 ng/mL. Conclusions: The results of this study show that the proportion of postmenopausal women with osteoporotic fractures who had vitamin D deficiency was higher than the proportion in previous reports that examined general postmenopausal women (35.2%e52.0%).
#25-hydroxyvitamin D #Osteoporosis #Fracture #Postmenopausal women #Bone mineral density

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참고문헌 (26)

참고문헌 신청
Cosman F / 2014 / Clinician’s guide to prevention and treatment of osteoporosis / Osteoporos Int 25:2359~2381 google schola Dawson-Hughes B / 2010 / IOF position statement : vitamin D recommendations for older adults / Osteoporos Int 21:1151~1154 google schola Hanley DA / 2010 / Vitamin D in adult health and disease: a review and guideline statement from Osteoporosis Canada / CMAJ (Can Med Assoc J) 182:E610~E618 google schola Holick MF / 2011 / Evaluation, treatment, and prevention of vitamin D deficiency : an Endocrine Society clinical practice guideline / J Clin Endocrinol Metab 96:1911~1930 google schola Okazaki R / 2017 / Assessment criteria for vitamin D deficiency/insufficiency in Japan : proposal by an expert panel supported by the research program of intractable diseases, ministry of health, labour and welfare, Japan, the Japanese society for bone and mineral research and the Japan endocrine society [opinion] / J Bone Miner Metab 35:1~5 google schola

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