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Short-term Effect of Intravitreal Dexamethasone Implant on Diabetic Macular Edema with Epiretinal Membrane
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망막앞막이 동반된 당뇨황반부종에서 유리체내 덱사메타손 임플란트 삽입술의 단기 치료 효과

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Type
Academic journal
Author
Donghyoun Noh (Department of Ophthalmology Yeungnam University College of Medicine) Jang Hwan Ahn (Department of Ophthalmology Yeungnam University College of Medicine) Jun Yeop Lee (Department of Ophthalmology Yeungnam University College of Medicine) Min Sagong (Department of Ophthalmology Yeungnam University College of Medicine)
Journal
한국망막학회 Journal of Retina Journal of Retina Vol.2 No.2 KCI Accredited Journals
Published
2017.1
Pages
68 - 75 (8page)

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Short-term Effect of Intravitreal Dexamethasone Implant on Diabetic Macular Edema with Epiretinal Membrane
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Purpose: To assess the short term effect of an intravitreal dexamethasone implant on diabetic macular edema (DME) with epiretinal membrane (ERM). Methods: We conducted a retrospective study including 39 eyes of 39 patients with DME who underwent intravitreal dexamethasone implant injection and were able to be observed for more than 6 months. Patients were divided into two groups according to presence or absence of ERM from March 2015 to June 2016. Results: Thirteen DME eyes with ERM and 26 DME eyes without ERM were enrolled. The classification of ERM was grade 0 in 5 (38.5%) eyes, grade 1 in 7 eyes (53.8%) and grade 2 in 1 eye (7.7%). There was no difference in best corrected visual acuity (BCVA) and central macular thickness (CMT) between the DME with ERM group and the DME without ERM group at baseline. After the injection, there was no difference in mean BCVA and mean CMT between the two groups at 1, 3, and 6 months. DME without ERM group showed a significant decrease in CMT compared to baseline at 1, 3, and 6 months (p < 0.001, p = 0.003, p = 0.001, respectively). The DME with ERM group showed a significant decrease in CMT compared to baseline at 1 and 3 months, but no difference at 6 months (p = 0.048, p = 0.024, p = 0.275, respectively). Conclusions: Intravitreal dexamethasone implantation may be a useful treatment modality for patients with DME with ERM, but the duration of the anatomical improvement may be shorter than that for patients with DME without ERM.

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References (43)

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Otani T / 1999 / Patterns of diabetic macular edema with optical coherence tomography / Am J Ophthalmol 127:688~693 google schola Yannuzzi LA / 1984 / Peripheral retinal detachments and retinal pigment epithelial atrophic tracts secondary to central serous pigment epitheliopathy / Ophthalmology 91:1554~1572 google schola Rechtman E / 2007 / Pharmacologic therapies for diabetic retinopathy and diabetic macular edema / Clin Ophthalmol 1:383~391 google schola Antcliff RJ / 1999 / The pathogenesis of edema in diabetic maculopathy / Semin Ophthalmol 14:223~232 google schola 1987 / Treatment techniques and clinical guidelines for photocoagulation of diabetic macular edema. Early Treatment Diabetic Retinopathy Study Report Number 2. Early Treatment Diabetic Retinopathy Study Research Group / Ophthalmology 94:761~774 google schola

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