지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 730 - 740 (11page)
- DOI
- 10.3947/ic.2021.0111
이용수
초록· 키워드
오류제보하기
Introduction: Zika virus (ZIKV), a mosquito-borne flavivirus, causes the outbreaks of Latin America in 2015 - 2016, with the incidence of neurological complications. Sunitinib malate, an orally bioavailable malate salt of the tyrosine kinase inhibitor, is suggested as a broadspectrum antiviral agent against emerging viruses like severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2.
Materials and Methods: This study investigated the antiviral efficacy and antiviral mechanisms of sunitinib malate against ZIKV infection using cytopathic effect reduction, virus yield, and time-of-addition assays.
Results: Sunitinib malate concentration-dependently reduced ZIKV-induced cytopathic effect, the expression of viral proteins, and ZIKV yield in supernatant with 50% inhibitory concentration (IC50) value of 0.015 μM, and the selectivity index of greater than 100 against ZIKV infection, respectively. Sunitinib malate had multiple antiviral actions during entry and post-entry stages of ZIKV replication. Sunitinib malate treatment at entry stage significantly reduced the levels of ZIKV RNA replication with the reduction of (+) RNA to (-) RNA ratio and the production of new intracellular infectious particles in infected cells. The treatment at post-entry stage caused a concentration-dependent increase in the levels of ZIKV (+) RNA and (-) RNA in infected cells, along with enlarging the ratio of (+) RNA to (-) RNA, but caused a pointed increase in the titer of intracellular infectious particles by 0.01 and 0.1 μM, and a substantial decrease in the titer of intracellular infectious particles by 1 μM.
Conclusion: The study discovered the antiviral actions of sunitinib malate against ZIKV infection, demonstrating a repurposed, host-targeted approach to identify potential antiviral drugs for treating emerging and global viral diseases.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Lindenbach BD / 2006 / Fields Virology / Lippincott Williams & Wilkins :1101~1152
Pan American Health Organization (PAHO) / World Health Organization (WHO). Zika - Epidemiological update
Duffy MR / 2009 / Zika virus outbreak on Yap Island, Federated States of Micronesia / N Engl J Med 360:2536~2543
Lanciotti RS / 2008 / Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007 / Emerg Infect Dis 14:1232~1239
Calvet G / 2016 / Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil : a case study / Lancet Infect Dis 16:653~660
Pan American Health Organization (PAHO) / World Health Organization (WHO). Zika - Epidemiological update
Duffy MR / 2009 / Zika virus outbreak on Yap Island, Federated States of Micronesia / N Engl J Med 360:2536~2543
Lanciotti RS / 2008 / Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007 / Emerg Infect Dis 14:1232~1239
Calvet G / 2016 / Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil : a case study / Lancet Infect Dis 16:653~660
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