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논문 기본 정보

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저자정보
Kang Yeo Wool (Department of Internal Medicine Dong-A University College of Medicine Busan Korea.) Baek Yang Hyun (Department of Internal Medicine Dong-A University College of Medicine Busan Korea.) Lee Sung Wook (Department of Internal Medicine Dong-A University College of Medicine Busan Korea.) Park Sung-Jae (Department of Internal Medicine Inje University Busan Paik Hospital Busan Korea.) Yoon Jun Sik (Department of Internal Medicine Inje University Busan Paik Hospital Busan Korea.) Yoon Ki Tae (Department of Internal Medicine Pusan National University Yangsan Hospital Yangsan Korea.) Hong Youngmi (Department of Internal Medicine Pusan National University Yangsan Hospital Yangsan Korea.) Heo Nae-Yun (Department of Internal Medicine Inje University Haeundae Paik Hospital Busan Korea.) Seo Kwang Il (Department of Internal Medicine Kosin University Gospel Hospital Busan Korea.) Lee Sang Soo (Department of Internal Medicine Gyeongsang National University School of Medicine and Gyeongsang Na) Cho Hyun Chin (Department of Internal Medicine College of Medicine Gyeongsang National University Jinju Korea.) Shin Jung Woo (Department of Internal Medicine Ulsan University College of Medicine Ulsan Korea.)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.36 No.21
발행연도
2021.1
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1 - 11 (11page)

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Background: The advancement of treatment with direct-acting antiviral (DAA) agents has improved the cure rate of hepatitis C virus (HCV) infection close to 100%. The aim of our study was to assess the real-world effectiveness and safety of DAA regimens for the treatment of patients with chronic HCV genotype 2. Methods: We retrospectively analyzed the clinical data of patients treated with sofosbuvir plus ribavirin (SOF + RBV) or glecaprevir/pibrentasvir (G/P) for chronic HCV genotype 2 infection at seven university hospitals in the Korean southeast region. Results: SOF + RBV therapy produced an 89% and 98.3% sustained virologic response 12 week (SVR12) after treatment completion in the full analysis set and per-protocol set, respectively, and the corresponding values for G/P therapy were 89.5% and 99.2%, respectively. The difference between the treatments was probably because 6.2% (59/953) of patients in the SOF + RBV group did not complete the treatment and 9.8% (14/143) in the G/P group did not test HCV RNA after treatment completion. Adverse events (A/Es) were reported in 59.7% (569/953) and 25.9% (37/143) of the SOF + RBV and G/P groups, respectively. In the SOF + RBV group, 12 (1.26%) patients discontinued treatment owing to A/Es, whereas no patients discontinued treatment because of A/Es in the G/P group. Conclusion: In both treatment groups, SVR was high when treatment was completed. However, there was a high dropout rate in the SOF + RBV group, and the dropout analysis showed that these were patients with liver cirrhosis (LC; 43/285, 15.1%), especially those with decompensated LC (12/32, 37.5%). Therefore, an early initiation of antiviral therapy is recommended for a successful outcome before liver function declines. Furthermore, patients with decompensated LC who are considered candidates for SOF + RBV treatment should be carefully monitored to ensure that their treatment is completed, especially those with low hemoglobin and high alanine transaminase.
#Chronic Hepatitis C #Direct-acting Antiviral #Effectiveness #Safety

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참고문헌 (31)

참고문헌 신청
Kao JH / 2016 / Hepatitis C virus infection in Taiwan : past, present, and future / J Formos Med Assoc 115(2):65~66 google schola Liu CH / 2014 / Nanomedicines in the treatment of hepatitis C virus infection in Asian patients : optimizing use of peginterferon alfa / Int J Nanomedicine 9:2051~2067 google schola European Association for the Study of the Liver / 2018 / EASL recommendations on treatment of hepatitis C 2018 / J Hepatol 69(2):461~511 google schola European Association for Study of Liver / 2014 / EASL clinical practice guidelines : management of hepatitis C virus infection / J Hepatol 60(2):392~420 google schola Prenner SB / 2017 / Hepatocellular carcinoma decreases the chance of successful hepatitis C virus therapy with direct-acting antivirals / J Hepatol 66(6):1173~1181 google schola

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