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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 477 - 492 (16page)
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BACKGROUND: Stem cell is currently playing a major role in the treatment of number of incurable diseases via transplantation therapy. The objective of this study was to determine the osteogenic potential of allogenic and xenogenic bone-derived MSC seeded on a hydroxyapatite (HA/TCP) bioceramic construct in critical size bone defect (CSD) in rabbits. METHODS: A 15 mm long radial osteotomy was performed unilaterally in thirty-six rabbits divided equally in six groups. Bone defects were filled with bioscaffold seeded with autologous, allogenic, ovine, canine BMSCs and cell free bioscaffold block in groups A, B, C, D and E respectively. An empty defect served as the control group. RESULTS: The radiological, histological and SEM observations depicted better and early signs of new bone formation and bridging bone/implant interfaces in the animals of group A followed by B. Both xenogenous MSC-HA/TCP construct also accelerated the healing of critical sized bone defect. There was no sign of any inflammatory reaction in the xenogenic composite scaffold group of animals confirmed their well acceptance by the host body. CONCLUSION: In vivo experiments in rabbit CSD model confirmed that autogenous, allogenous and xenogenous BMSC seeded on bioscaffold promoted faster healing of critical size defects. Hence, we may suggest that BMSCs are suitable for bone formation in fracture healing and non-union.
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참고문헌 (50)
참고문헌 신청
Lane JM / 1999 / Biosynthetic bone grafting / Clin Orthop Relat Res 367:S107~S117
Barry FP / 2004 / Mesenchymal stem cells: clinical applications and biological characterization / Int J Biochem Cell Biol 36:568~584
Barrilleaux B / 2006 / Review: ex vivo engineering of living tissues with adult stem cells / Tissue Eng 12:3007~3019
Niemeyer P / 2010 / Transplantation of human mesenchymal stem cells in a non-autogenous setting for bone regeneration in a rabbit critical-size defect model / Acta Biomater 6:900~908
Kim HJ / 2008 / Transplanted xenogenic bone marrow stem cells survive and generate new bone formation in the posterolateral lumbar spine of non-immunosuppressed rabbits / Eur Spine J 17:1515~1521
Barry FP / 2004 / Mesenchymal stem cells: clinical applications and biological characterization / Int J Biochem Cell Biol 36:568~584
Barrilleaux B / 2006 / Review: ex vivo engineering of living tissues with adult stem cells / Tissue Eng 12:3007~3019
Niemeyer P / 2010 / Transplantation of human mesenchymal stem cells in a non-autogenous setting for bone regeneration in a rabbit critical-size defect model / Acta Biomater 6:900~908
Kim HJ / 2008 / Transplanted xenogenic bone marrow stem cells survive and generate new bone formation in the posterolateral lumbar spine of non-immunosuppressed rabbits / Eur Spine J 17:1515~1521
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