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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 437 - 445 (9page)
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초록· 키워드
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Hydroxyapatite (HA) blocks as an alternative material for autogenous onlay bone grafts are regarded as an insufficient substitute for osseointegration of dental implant. In this study, we evaluated the effects of dog mesenchymal stromal cells (dMSCs) with or without bone morphogenetic protein-2 (BMP) on new peri-implant bone formation after HA block graft. In four mandibular bone defects (8×8×6 mm each) in five beagle dogs, dental implants were placed with HA block loaded with autogenous dMSCs with or without BMP-2. Animals were sacrificed at eight weeks, and bone healing was evaluated among four groups consisting of 1) HA alone as a control, 2) HA+dMSCs, 3) HA+BMP-2, and 4) HA+dMSCs+BMP-2. According to histomorphometric evaluation, the MSC+BMP-2 group and the BMP-2 group showed significantly higher bone-implant-contact (BIC) length than the MSC group, while there was no significant difference in new bone formation among the groups. According to micro-CT analysis, bone volume and bone mineral density were significantly higher in the MSC+BMP-2 group compared with the control group (p<0.01 and p<0.05, respectively). BIC was significantly higher in the MSC+BMP-2 group than both the control and MSC groups (p<0.01 and p<0.05, respectively). In conclusion, our results showed that bone regeneration at peri-implant bone defects grafted with HA blocks was significantly increased by dual delivery of MSCs and BMP-2. Conversely, HA blocks with MSC or BMP-2 alone did not allow for efficient peri-implant bone regeneration.
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등록된 정보가 없습니다.
참고문헌 (37)
참고문헌 신청
Brånemark PI / 1983 / Osseointegration and its experimental background / J Prosthet Dent 50:399~410
Buser D / 1999 / Localized ridge augmentation with autografts and barrier membranes / Periodontol 2000 19:151~163
Laurie SW / 1984 / Donor-site morbidity after harvesting rib and iliac bone / Plast Reconstr Surg 73:933~938
Carlson ER / 1995 / The potential for HIV transmission through allogeneic bone. A review of risks and safety / Oral Surg Oral Med Oral Pathol Oral Radiol Endod 80:17~23
Stevenson S / 1987 / The immune response to osteochondral allografts in dogs / J Bone Joint Surg Am 69:573~582
Buser D / 1999 / Localized ridge augmentation with autografts and barrier membranes / Periodontol 2000 19:151~163
Laurie SW / 1984 / Donor-site morbidity after harvesting rib and iliac bone / Plast Reconstr Surg 73:933~938
Carlson ER / 1995 / The potential for HIV transmission through allogeneic bone. A review of risks and safety / Oral Surg Oral Med Oral Pathol Oral Radiol Endod 80:17~23
Stevenson S / 1987 / The immune response to osteochondral allografts in dogs / J Bone Joint Surg Am 69:573~582
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