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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 705 - 715 (11page)
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초록· 키워드
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Background: Beta-tricalcium phosphate (β-TCP) has been employed successfully as a synthetic graft material in maxillary sinus floor augmentation (MSFA) for placing dental implants. However, the lack of osteogenic and osteoinductive properties of this substitute invariably results in bone regeneration of low quality and quantity. The purpose of this study was to determine whether loading dentin matrix protein-1 (DMP1) gene-modified bone marrow mesenchymal stem cells (BMSCs) onto β-TCP promoted bone regeneration and osteointegration of dental implants in MSFA of dogs. Methods: BMSCs were transduced with a lentiviral vector overexpressing the DMP1 gene (Lenti-DMP1) and with a lentiviral vector overexpressing enhanced green fluorescent protein (Lenti-EGFP) in vitro and were loaded into β-TCP scaffolds for autologous sinus grafting. Beagles received bilateral MSFA with four biomaterials (① Lenti-DMP1-transduced BMSCs/β-TCP, ② Lenti-EGFP-transduced BMSCs/β-TCP, ③ BMSCs/β-TCP, ④ β-TCP) and simultaneous implant placement at each sinus. Twelve weeks post operation, the maxillae were explanted, and every sinus was evaluated by radiographic observation, micro-CT and histological analysis. The osteogenic outcomes of bone regeneration and osseointegration were compared between the four groups. Results: The sinuses grafted with Lenti-DMP1-transduced BMSCs/β-TCP constructs presented a significantly higher increase in compact radiopaque area, higher local bone mineral densities, greater bone-implant contact and greater bone density when compared to other three groups. Conclusion: These results demonstrated that combinations of β-TCP and DMP1 gene-modified BMSCs could be used to construct tissue-engineered bone to enhance mineralization of the regenerated bone and osseointegration of dental implants in MSFA.
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참고문헌 (37)
참고문헌 신청
Sverzut AT / 2015 / Clinical, radiographic, and histological analyses of calcium phosphate cement as filling material in maxillary sinus lift surgery / Clin Oral Implants Res 26:633~638
Aludden HC / 2017 / Lateral ridge augmentation with Bio-Oss alone or Bio-Oss mixed with particulate autogenous bone graft : a systematic review / Int J Oral Maxillofac Surg 46:1030~1038
Starch-Jensen T / 2018 / A systematic review and meta-analysis of long-term studies(five or more years)assessing maxillary sinus floor augmentation / Int J Oral Maxillofac Surg 47:103~116
Alayan J / 2018 / A prospective controlled trial comparing xenograft/autogenous bone and collagen-stabilized xenograft for maxillary sinus augmentation-complications, patient-reported outcomes and volumetric analysis / Clin Oral Implants Res 29:248~262
Nino-Sandoval TC / 2019 / Efficacy of stem cells in maxillary sinus floor augmentation : systematic review and meta-analysis / Int J Oral Maxillofac Surg 48:1355~1366
Aludden HC / 2017 / Lateral ridge augmentation with Bio-Oss alone or Bio-Oss mixed with particulate autogenous bone graft : a systematic review / Int J Oral Maxillofac Surg 46:1030~1038
Starch-Jensen T / 2018 / A systematic review and meta-analysis of long-term studies(five or more years)assessing maxillary sinus floor augmentation / Int J Oral Maxillofac Surg 47:103~116
Alayan J / 2018 / A prospective controlled trial comparing xenograft/autogenous bone and collagen-stabilized xenograft for maxillary sinus augmentation-complications, patient-reported outcomes and volumetric analysis / Clin Oral Implants Res 29:248~262
Nino-Sandoval TC / 2019 / Efficacy of stem cells in maxillary sinus floor augmentation : systematic review and meta-analysis / Int J Oral Maxillofac Surg 48:1355~1366
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